Department of Medicine, The Doherty Institute, The University of Melbourne, 792 Elizabeth Street, Melbourne, VIC, 3000, Australia.
Immunol Cell Biol. 2020 Apr;98(4):264-275. doi: 10.1111/imcb.12320. Epub 2020 Feb 24.
Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect against disease varies markedly. Research has revealed that functional properties of antibodies determine their role in protection against parasites. Investigations of antibodies against Plasmodium spp. have demonstrated a variety of functional activities, ranging from invasion inhibition and parasite growth inhibition to antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity. These activities have been demonstrated with a large variety of parasite molecules at multiple life cycle stages, highlighting the importance of functional antibody responses in malaria. Other parasitic infections have not yet been investigated in similar detail, but these mechanisms are likely to operate in nonmalarial parasitic infections as well. In this report, we review data on the role of functional antibody responses in protection from parasitic infections, highlighting discoveries in malaria, a parasite for which our knowledge base is the most advanced.
许多寄生虫感染会刺激其哺乳动物宿主产生抗体反应。这些抗体对疾病的保护能力差异很大。研究表明，抗体的功能特性决定了其在防治寄生虫中的作用。对疟原虫属抗体的研究表明，抗体具有多种功能活性，包括抑制入侵和寄生虫生长，以及抗体依赖性细胞吞噬和抗体依赖性细胞毒性。这些活性已经在多种寄生虫分子和多个生命周期阶段得到证实，突出了功能性抗体反应在疟疾中的重要性。其他寄生虫感染尚未进行类似的详细研究，但这些机制可能也存在于非疟疾寄生虫感染中。在本报告中，我们综述了功能性抗体反应在防治寄生虫感染中的作用的数据，重点介绍了在疟疾方面的发现，因为我们对这种寄生虫的了解是最先进的。
