Department of Pediatrics, Istanbul Training and Education Hospital, İstanbul, Turkey.
Pediatr Int. 2020 Apr;62(4):467-476. doi: 10.1111/ped.14176.
Childhood obesity is a growing and significant problem worldwide. Asprosin is a novel adipokine that is significantly associated with glucose and insulin production in the liver during fasting. In the present study, we aimed to demonstrate whether there would be differences between obese, overweight, and normal weight children in terms of serum asprosin levels.
Forty-four children with obesity, 54 overweight children, and 60 normal weight children were compared in terms of serum asprosin levels and other anthropometric, biochemical, and hormonal parameters that are associated with being overweight and with obesity.
Serum asprosin levels were found to be significantly different between groups: 70.903 ± 17.49 ng/mL, 79.744 ± 29.54 ng/mL, and 106.293 ± 122.69 ng/mL in normal weight, overweight, and obese children respectively. Post-hoc analysis revealed that the asprosin level was significantly higher in obese children compared with normal weight children (P = 0.009). Additionally, asprosin was found to be a predictor of obesity in multiple regression analysis.
Our study is the first to demonstrate increased levels of asprosin in obese children compared with normal weight children. Further studies are needed to demonstrate the role of asprosin in the etiology of childhood obesity, as well as other diseases that might be associated with effects of asprosin.
儿童肥胖是全球日益严重且重大的问题。天门冬氨酸是一种新型脂肪因子，在空腹时与肝脏中葡萄糖和胰岛素的产生有显著关联。本研究旨在证明肥胖、超重和正常体重儿童的血清天门冬氨酸水平是否存在差异。
比较了 44 名肥胖儿童、54 名超重儿童和 60 名正常体重儿童的血清天门冬氨酸水平以及与超重和肥胖相关的其他人体测量、生化和激素参数。
血清天门冬氨酸水平在各组之间存在显著差异：正常体重、超重和肥胖儿童的血清天门冬氨酸水平分别为 70.903±17.49ng/mL、79.744±29.54ng/mL 和 106.293±122.69ng/mL。事后分析显示，肥胖儿童的天门冬氨酸水平明显高于正常体重儿童（P=0.009）。此外，多元回归分析显示天门冬氨酸是肥胖的预测因子。
本研究首次证明肥胖儿童的天门冬氨酸水平高于正常体重儿童。需要进一步研究来证明天门冬氨酸在儿童肥胖病因学以及可能与天门冬氨酸作用相关的其他疾病中的作用。
