Department of Periodontology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Clin Oral Investig. 2024 Jan 13;28(1):91. doi: 10.1007/s00784-024-05494-9.
A newly discovered adipokine known asprosin in serum and saliva in patients with periodontitis has not been explored. The aim of this study was to determine the relationship between serum and saliva asprosin levels and periodontitis by grouping it according to body mass index (BMI).
The study was conducted on 65 systemically healthy patients (35 patients with periodontitis (periodontitis group), 30 periodontally healthy patients (control group)). In each patient, age, BMI, and clinical periodontal parameters (plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment level (CAL)) were evaluated. Statistical analyses were conducted utilizing the Student t-test, ANOVA, and Pearson correlation analysis. For the significance level of the tests, p<0.05 were accepted.
The serum and saliva were collected to assess asprosin levels. Both the serum and saliva asprosin levels were statistically significantly higher in the periodontitis group than in the control group (p<0.001). Saliva and serum asprosin levels were directly proportional to the severity of the periodontal disease (p<0.05). Asprosin levels were higher in patients with a higher BMI (p<0.05).
Asprosin levels were increased in periodontitis, and even a high BMI status apparently affected the levels of this hormone. It is thought that asprosin may be a useful biomarker in evaluating the relationship between periodontal status and BMI.
Asprosin may be a useful parameter as a biomarker of periodontal disease progression. However, BMI status should be considered when evaluating asprosin levels in patients with periodontitis.
在牙周炎患者的血清和唾液中发现了一种新的脂肪因子——脯氨酸，但其与牙周炎的关系尚未得到研究。本研究旨在根据体重指数（BMI）对患者进行分组，以确定血清和唾液中脯氨酸水平与牙周炎之间的关系。
本研究共纳入 65 名系统健康的患者（牙周炎患者 35 例（牙周炎组），牙周健康患者 30 例（对照组））。在每位患者中，评估了年龄、BMI 和临床牙周参数（菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）和临床附着水平（CAL））。采用 Student t 检验、方差分析和 Pearson 相关分析进行统计分析。检验的显著性水平为 p<0.05。
采集血清和唾液以评估脯氨酸水平。牙周炎组的血清和唾液脯氨酸水平均明显高于对照组（p<0.001）。唾液和血清脯氨酸水平与牙周病的严重程度呈正相关（p<0.05）。BMI 较高的患者脯氨酸水平较高（p<0.05）。
牙周炎患者的脯氨酸水平升高，甚至高 BMI 状态明显影响该激素的水平。认为脯氨酸可能是评估牙周状况与 BMI 之间关系的有用生物标志物。
脯氨酸可能是评估牙周病进展的有用生物标志物。然而，在评估牙周炎患者的脯氨酸水平时，应考虑 BMI 状态。
