Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, India.
College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.
Curr Pharm Des. 2020;26(15):1712-1728. doi: 10.2174/1381612826666200128095248.
Flavonoids are low molecular weight, polyphenolic phytochemicals, obtained from secondary metabolism of various plant compounds. They have a spectrum of pharmacological efficacies, including potential anticancer efficacy. Natural flavonoids are present in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. Flavonoids can attenuate or inhibit the initiation, promotion and progression of cancer by modulating various enzymes and receptors in diverse pathways that involve cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis. Furthermore, in vitro, flavonoids have been shown to reverse multidrug resistance when used as chemo-adjuvants. Flavonoids (both natural and synthetic analogues) interact with several oncogenic targets through dependent and independent mechanisms to mediate their anticancer efficacy in different types of cancer cells.
类黄酮是低分子量、多酚类植物化学物质，来源于各种植物化合物的次级代谢。它们具有多种药理作用，包括潜在的抗癌作用。天然类黄酮存在于水果、蔬菜、谷物、树皮、根、茎、花、茶和酒中。类黄酮可以通过调节涉及细胞增殖、分化、凋亡、炎症、血管生成和转移的不同途径中的各种酶和受体来减轻或抑制癌症的发生、促进和进展。此外，体外研究表明，类黄酮作为化疗辅助剂使用时可以逆转多药耐药性。类黄酮（天然和合成类似物）通过依赖和独立的机制与多个致癌靶点相互作用，从而在不同类型的癌细胞中发挥其抗癌作用。
