生物碱类抗癌药物：近 5 年中国专利分析。
Alkaloids as Anticancer Agents: A Review of Chinese Patents in Recent 5 Years.
机构信息
Department of Pharmacology, School of Basic Medicine, Capital Medical University, Beijing 100069, China.
Department of Pharmacology, School of Pharmacy, Southwest Medical University, Sichuan 646000, China.
出版信息
Recent Pat Anticancer Drug Discov. 2020;15(1):2-13. doi: 10.2174/1574892815666200131120618.
BACKGROUND
In recent years, many novel alkaloids with anticancer activity have been found in China, and some of them are promising for developing as anticancer agents.
OBJECTIVE
This review aims to provide a comprehensive overview of the information about alkaloid anticancer agents disclosed in Chinese patents, and discusses their potential to be developed as anticancer drugs used clinically.
METHODS
Anticancer alkaloids disclosed in Chinese patents in recent 5 years were presented according to their mode of actions. Their study results published on PubMed, and SciDirect databases were presented.
RESULTS
More than one hundred anticancer alkaloids were disclosed in Chinese patents and their mode of action referred to arresting cell cycle, inhibiting protein kinases, affecting DNA synthesis and p53 expression, etc. Conclusion: Many newly found alkaloids displayed potent anticancer activity both in vitro and in vivo, and some of the anticancer alkaloids acted as protein kinase inhibitors or CDK inhibitors possess the potential for developing as novel anticancer agents.
背景
近年来，中国发现了许多具有抗癌活性的新型生物碱，其中一些具有开发成抗癌药物的潜力。
目的
本综述旨在全面概述中国专利中披露的生物碱抗癌剂的信息，并讨论其作为临床抗癌药物开发的潜力。
方法
根据作用方式，展示了近 5 年中国专利中披露的抗癌生物碱。展示了在 PubMed 和 SciDirect 数据库上发表的他们的研究结果。
结果
中国专利中披露了 100 多种抗癌生物碱，其作用方式包括细胞周期阻滞、抑制蛋白激酶、影响 DNA 合成和 p53 表达等。
结论
许多新发现的生物碱在体外和体内均表现出强大的抗癌活性，一些作为蛋白激酶抑制剂或 CDK 抑制剂的抗癌生物碱具有开发成新型抗癌药物的潜力。
Zotero 插件