Alvarez-Larrotta Catalina, Arango Eliana María, Carmona-Fonseca Jaime
Universidad de Antioquia, Medellín, Colombia.
J Infect Dev Ctries. 2018 Oct 31;12(10):812-823. doi: 10.3855/jidc.10337.
Parasitic infections are an important cause of global morbidity and mortality and are highly prevalent in "underdeveloped" countries. The presence of parasitic infections is associated with modulation of the immune system and changes in the response to bacterial and viral vaccines. The objective of this review was to compile, summarize and analyze information about immunomodulation by parasitic infections and its effects on the immune response to vaccines. We also identified the parasites most associated with immunomodulation of vaccine responses and those vaccines most affected. In addition, articles evaluating the effect of chemoprophylaxis for malaria on the immune response against vaccines were considered. The most affected vaccines are Bacillus Calmette-Guérin and bacterial polysaccharide vaccines. Malaria is the infection most associated with decreased response to vaccines; however, there are discordant results. Chemoprophylaxis for malaria did not change the immune response to vaccination. While parasitic infections can alter the immune response to vaccination, it is important to clarify the discrepancies and establish the mechanisms.
寄生虫感染是全球发病和死亡的重要原因，在“不发达国家”高度流行。寄生虫感染的存在与免疫系统的调节以及对细菌和病毒疫苗反应的变化有关。本综述的目的是汇编、总结和分析有关寄生虫感染免疫调节及其对疫苗免疫反应影响的信息。我们还确定了与疫苗反应免疫调节最相关的寄生虫以及受影响最大的那些疫苗。此外，还考虑了评估疟疾化学预防对疫苗免疫反应影响的文章。受影响最大的疫苗是卡介苗和细菌多糖疫苗。疟疾是与疫苗反应降低最相关的感染；然而，结果并不一致。疟疾化学预防并未改变疫苗接种的免疫反应。虽然寄生虫感染可改变疫苗接种的免疫反应，但澄清差异并确定机制很重要。
