Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, St. James' Hospital Campus, Dublin, Ireland.
Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Trinity College Dublin, St. James' Hospital Campus, Dublin, Ireland; Irish Centre for Vascular Biology, Trinity College Dublin, Dublin, Ireland.
Biochem Pharmacol. 2020 Apr;174:113831. doi: 10.1016/j.bcp.2020.113831. Epub 2020 Jan 28.
Innate sensing of viruses by cytosolic nucleic acid sensors is a key feature of anti-viral immunity against these pathogens. The DNA sensing pathway through the sensor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimulator of interferon genes (STING) has emerged in recent years as a key, front-line means of driving interferons and pro-inflammatory cytokines in response to DNA virus infection in vertebrates. Unsurprisingly, many DNA viruses have evolved effective inhibitors of this signalling system which target at a wide variety of points from sensing all the way down to the activation of Interferon Regulatory Factor (IRF)-family and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-family transcription factors which drive a program of pro-inflammatory and anti-viral gene expression. Here we review DNA viruses that have been shown to inhibit this pathway and the inhibitors they have evolved to do it.
先天感知病毒的细胞质核酸传感器是抗病毒免疫这些病原体的一个关键特征。近年来，通过传感器环鸟苷酸-腺苷酸合酶（cGAS）及其下游效应物干扰素基因刺激物（STING）的 DNA 感应途径已成为脊椎动物针对 DNA 病毒感染驱动干扰素和促炎细胞因子的关键一线手段。毫不奇怪，许多 DNA 病毒已经进化出有效的信号系统抑制剂，这些抑制剂针对从感应到干扰素调节因子（IRF）家族和核因子 kappa 轻链增强子的激活 B 细胞（NF-κB）家族转录因子的各种靶点，这些转录因子驱动促炎和抗病毒基因表达的程序。在这里，我们回顾了已被证明抑制该途径的 DNA 病毒及其进化出的抑制剂。
