Spinal leptomeningeal oligodendrogliomatosis after resection of cerebral anaplastic oligodendoglioma with 1p19q Co-deletion - A case report.

Anaplastic Oligodendroglioma has a better prognosis in the presence of 1p19q co-deletion and IDH-1 mutation but spinal leptomeningeal dissemination of cerebral anaplastic oligodendroglioma is a rare occurrence. We describe the case of a 47 year old man with spinal leptomeningeal dissemination eight months after resection of an anaplastic cerebral oligodendroglioma presenting with encephalitic features. We present the radiological, biochemical, intraoperative and histological features of this syndrome. Despite resolution of symptoms with corticosteroid treatment and favourable biochemical markers, prognosis remains poor when spinal leptomeningeal disease is present.