Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy; Department of Translational Research, N.T.M.S., University of Pisa, Italy.
Department of Translational Research, N.T.M.S., University of Pisa, Italy; Life Science Research Centre, Faculty of Science, University of Ostrava, Czech Republic.
Acta Trop. 2020 May;205:105381. doi: 10.1016/j.actatropica.2020.105381. Epub 2020 Jan 30.
Infection with helminths in sub-Saharan Africa could modulate the immune response towards Plasmodium falciparum as well as susceptibility to malaria infection and disease. The aim of this study is to assess the antibody responses to helminths species in malaria-exposed populations from Burkina Faso. Plasma samples were collected in rural villages inhabited by Fulani, Mossi and Rimaibe communities, and IgG against parasitic helminths were measured by ELISA. The prevalence of IgG against antigens of Strongyloides stercoralis, Wuchereria bancrofti and Schistosoma haematobium (Soluble Egg Antigen, SEA) was 5%, 16% and 63% respectively, in line with estimates of infection prevalence in the region for the three parasites. Anti-SEA IgG prevalence was highest at 10-20 years of age, higher in males than females, and did not show differences between ethnic groups. However, the Fulani showed lower levels of anti-SEA IgG suggesting that lighter S. haematobium infections may occur in the ethnic group known for a marked lower susceptibility to P. falciparum. The present data support the use of serological methods for integrated surveillance of neglected tropical diseases such as soil-transmitted helminths, lymphatic filariasis and bilharzia. Furthermore, as helminth infections might promote downregulation of immune responses against intracellular pathogens, the observation of lower anti-SEA IgG levels in the malaria resistant Fulani population warrants further investigation into the immunological cross-talk between S. haematobium and P. falciparum in this geographical region.
在撒哈拉以南非洲，寄生虫感染可能会调节针对恶性疟原虫的免疫反应以及对疟疾感染和疾病的易感性。本研究旨在评估布基纳法索疟疾流行地区人群对寄生虫种类的抗体反应。在富拉尼人、莫西人和里马贝社区居住的农村村庄采集血浆样本，并通过 ELISA 测量针对寄生虫的 IgG 抗体。针对旋毛虫、班氏丝虫和埃及血吸虫（可溶性卵抗原，SEA）抗原的 IgG 抗体的流行率分别为 5%、16%和 63%，与该地区三种寄生虫的感染流行率估计值一致。抗-SEA IgG 的流行率在 10-20 岁时最高，男性高于女性，且在不同民族之间没有差异。然而，富拉尼人的抗-SEA IgG 水平较低，表明该民族的埃及血吸虫感染可能较轻，而该民族对恶性疟原虫的易感性明显较低。目前的数据支持使用血清学方法对土壤传播性蠕虫病、淋巴丝虫病和血吸虫病等被忽视的热带病进行综合监测。此外，由于寄生虫感染可能会下调针对细胞内病原体的免疫反应，因此在抗疟疾的富拉尼人群中观察到较低的抗-SEA IgG 水平，这表明需要进一步研究该地区埃及血吸虫和恶性疟原虫之间的免疫交叉对话。
