基于丙交酯的 3D 微腔阵列的 pH 依赖性降解特性及其对持续货物释放的影响。

pH dependent degradation properties of lactide based 3D microchamber arrays for sustained cargo release.

机构信息

Key Laboratory of Micro-systems and Micro-structures Manufacturing Ministry of Education, Harbin Institute of Technology, Harbin, 150001, China.

Max Plank Institute of Polymer Research, Ackermannweg 10, 55128, Mainz, Germany; School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, United Kingdom.

出版信息

Colloids Surf B Biointerfaces. 2020 Apr;188:110826. doi: 10.1016/j.colsurfb.2020.110826. Epub 2020 Jan 25.

DOI:10.1016/j.colsurfb.2020.110826

PMID:32007703

Abstract

Encapsulation of small water soluble molecules is important in a large variety of applications, ranging from medical substance releasing implants in the field of medicine over release of catalytically active substances in the field of chemical processing to anti-corrosion agents in industry. In this work polylactic acid (PLA) based hollow-structured microchamber (MC) arrays are fabricated via one-step dip coating of a silicone rubber stamp into PLA solution. These PLA MCs are able to retain small water soluble molecules (Rhodamine B) stably entrapped within aqueous environments. It is shown, that degradation of PLA MCs strongly depends on environmental conditions like surrounding pH and follows first order degradation kinetics. This pH dependent PLA MC degradation can be utilized to control the release kinetics of encapsulated cargo.

摘要

将小分子水溶性物质进行封装在很多领域都很重要，包括医学领域中的药物释放植入物、化学加工领域中的催化活性物质释放以及工业领域中的防腐剂等。在这项工作中，通过将硅橡胶印章浸入 PLA 溶液中一步法进行浸涂，制备了基于聚乳酸（PLA）的中空结构微腔（MC）阵列。这些 PLA MC 能够在水环境中稳定地保留被包封的小分子水溶性物质（若丹明 B）。结果表明，PLA MC 的降解强烈依赖于周围 pH 值等环境条件，并遵循一级降解动力学。这种 pH 值依赖的 PLA MC 降解可用于控制封装货物的释放动力学。