阴性及情感症状对精神分裂症快感缺失自我报告的影响。

The influence of negative and affective symptoms on anhedonia self-report in schizophrenia.

作者信息

Jarratt-Barnham Isaac, Saleh Youssuf, Husain Masud, Kirkpatrick Brian, Fernandez-Egea Emilio

机构信息

Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.

Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK..

出版信息

Compr Psychiatry. 2020 Jan 25;98:152165. doi: 10.1016/j.comppsych.2020.152165.

DOI:10.1016/j.comppsych.2020.152165

PMID:32007758

Abstract

BACKGROUND

Anhedonia, a symptom prevalent in schizophrenia patients, is thought to arise either within negative symptomatology or from secondary sources, such as depression. The common co-occurrence of these diseases complicates the assessment of anhedonia in schizophrenia.

METHOD

In a sample of 40 outpatients with chronic schizophrenia, we explored both the validity of the Snaith-Hamilton Pleasure Scale (SHAPS) self-report for anhedonia assessment and those factors influenced its scoring. We assessed negative symptoms using the Brief Negative Symptom Scale (BNSS), depression symptoms using the Calgary Depression Scale for Schizophrenia (CDSS) and cognitive impairment using the Brief Assessment of Cognition in Schizophrenia (BACS), before exploring associations between these scales.

RESULTS

The SHAPS was validated for use in schizophrenia. SHAPS scores were not associated with negative symptoms or cognitive impairment, but were linked to a single Depression symptom: Hopelessness (r = 0.52, p < 0.001).

CONCLUSIONS

SHAPS scores, therefore, appear to only reflect anticipatory anhedonia arising from the affective domain. We advocate the development of multi-faceted self-report measures to more holistically assess anhedonia in schizophrenia.

摘要

背景

快感缺失是精神分裂症患者中普遍存在的一种症状，被认为是在阴性症状中出现，或者源于诸如抑郁等继发因素。这些疾病的共同出现使得精神分裂症中快感缺失的评估变得复杂。

方法

在40名慢性精神分裂症门诊患者的样本中，我们探讨了斯奈斯 - 汉密尔顿快感量表（SHAPS）自评对快感缺失评估的有效性以及影响其评分的因素。在探究这些量表之间的关联之前，我们使用简明阴性症状量表（BNSS）评估阴性症状，使用精神分裂症卡尔加里抑郁量表（CDSS）评估抑郁症状，使用精神分裂症认知简明评估量表（BACS）评估认知障碍。