Y.Y. Leung, MB ChB, MD, Associate Professor, Duke-NUS Medical School, Department of Rheumatology and Immunology, Singapore General Hospital, Singapore
A.M. Orbai, MD, MHS, Assistant Professor of Medicine, Director Psoriatic Arthritis Program, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Rheumatol. 2021 Jan 1;48(1):58-66. doi: 10.3899/jrheum.191119. Epub 2020 Feb 1.
Numerous patient-reported outcome measures (PROM) exist for the measurement of physical function for psoriatic arthritis (PsA), but only a few are validated comprehensively. The objective of this project was to prioritize PROM for measuring physical function for potential incorporation into a standardized outcome measurement set for PsA.
A working group of 13 members including 2 patient research partners was formed. PROM measuring physical function in PsA were identified through a systematic literature review and recommendations by the working group. The rationale for inclusion and exclusion from the original list of existing PROM was thoroughly discussed and 2 rounds of Delphi exercises were conducted to achieve consensus.
Twelve PROM were reviewed and discussed. Six PROM were prioritized: Health Assessment Questionnaire (HAQ) and 4 modifications (HAQ-Disability Index, HAQ-Spondyloarthritis, modified HAQ, multidimensional HAQ), Medical Outcomes Study 36-item Short Form survey physical functioning domain, and the Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning module.
Through discussion and Delphi exercises, we achieved consensus to prioritize 6 physical function PROM for PsA. These 6 PROM will undergo further appraisal using the Outcome Measures in Rheumatology (OMERACT) Filter 2.1.
有许多针对银屑病关节炎（PsA）的患者报告结局测量（PROM）用于测量身体功能，但只有少数经过全面验证。本项目的目的是优先选择用于测量 PsA 身体功能的 PROM，以潜在纳入 PsA 的标准化结局测量集。
成立了一个由 13 名成员组成的工作组，其中包括 2 名患者研究伙伴。通过系统文献回顾和工作组的建议，确定了用于测量 PsA 身体功能的 PROM。对原始 PROM 列表中的纳入和排除的基本原理进行了深入讨论，并进行了 2 轮 Delphi 练习以达成共识。
共审查和讨论了 12 个 PROM。优先考虑了 6 个 PROM：健康评估问卷（HAQ）及其 4 种变体（HAQ 残疾指数、HAQ 脊柱关节炎、改良 HAQ、多维 HAQ）、医疗结局研究 36 项简短调查问卷的身体功能域以及患者报告结局测量信息系统（PROMIS）身体功能模块。
通过讨论和 Delphi 练习，我们就优先考虑用于评估 PsA 的 6 种身体功能 PROM 达成了共识。这 6 个 PROM 将使用风湿病结局测量（OMERACT）筛选器 2.1 进行进一步评估。
