Department of CAM, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Doctorate School, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.
Rev Neurosci. 2020 May 26;31(4):415-425. doi: 10.1515/revneuro-2019-0095.
The microbiota and microbiome and disruption of the gut-brain axis were linked to various metabolic, immunological, physiological, neurodevelopmental, and neuropsychiatric diseases. After a brief review of the relevant literature, we present our hypothesis that intestinal serotonin, produced by intestinal enterochromaffin cells, picked up and stored by circulating platelets, participates and has an important role in the regulation of membrane permeability in the intestine, brain, and other organs. In addition, intestinal serotonin may act as a hormone-like continuous regulatory signal for the whole body, including the brain. This regulatory signal function is mediated by platelets and is primarily dependent on and reflects the intestine's actual health condition. This hypothesis may partially explain why gut dysbiosis could be linked to various human pathological conditions as well as neurodevelopmental and neuropsychiatric disorders.
肠道微生物群和微生物组以及肠道-大脑轴的紊乱与各种代谢、免疫、生理、神经发育和神经精神疾病有关。在简要回顾相关文献后，我们提出了一个假设，即肠道中的 5-羟色胺由肠道嗜铬细胞产生，被循环血小板吸收和储存，参与并在肠道、大脑和其他器官的膜通透性调节中发挥重要作用。此外，肠道 5-羟色胺可能作为一种类似激素的全身持续调节信号，包括大脑。这种调节信号功能由血小板介导，主要取决于并反映肠道的实际健康状况。这一假设可能部分解释了为什么肠道菌群失调与各种人类病理状况以及神经发育和神经精神疾病有关。
