Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.
Amino Acids. 2020 Mar;52(3):499-503. doi: 10.1007/s00726-020-02819-2. Epub 2020 Feb 1.
A direct inhibiting effect of NO on the function of CAT-1 and -2A has been postulated to occur via nitrosylation of cysteine residues in the transporters. Neither the NO donor SNAP nor a mixture of SIN-1 and Spermine NONOate, that generates the strong nitrosating agent NO, reduced CAT-mediated L-arginine transport. Direct nitros(yl)ation does either not occur in CATs or does not affect their transport function. A regulatory effect of NO or nitrosating agents on CAT-mediated transport under physiological conditions seems, therefore, unlikely.
据推测，NO 通过对转运体中半胱氨酸残基的亚硝基化作用，直接抑制 CAT-1 和 -2A 的功能。NO 供体 SNAP 以及生成强亚硝化剂 NO 的 SIN-1 和 Spermine NONOate 混合物均未降低 CAT 介导的 L-精氨酸转运。CAT 中不会发生直接的亚硝（基）化作用，或者不会影响其转运功能。因此，在生理条件下，NO 或亚硝化剂对 CAT 介导的转运的调节作用似乎不太可能。
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