Gorabi Armita Mahdavi, Kiaie Nasim, Pirro Matteo, Bianconi Vanessa, Jamialahmadi Tannaz, Sahebkar Amirhossein
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy.
Heart Fail Rev. 2021 Sep;26(5):1259-1272. doi: 10.1007/s10741-020-09929-9.
Statins are well-known lipid-lowering drugs. The pleiotropic effects of statins have brought about some beneficial effects on improving the therapeutic outcomes of cell therapy and tissue engineering approaches. In this review, the impact of statins on mesenchymal stem cell behaviors including differentiation, apoptosis, proliferation, migration, and angiogenesis, as well as molecular pathways which are responsible for such phenomena, are discussed. A better understanding of pathways and mechanisms of statin-mediated effects on mesenchymal stem cells will pave the way for the expansion of statin applications. Furthermore, since designing a suitable carrier for statins is required to maintain a sufficient dose of active statins at the desired site of the body, different systems for local delivery of statins are also reviewed.
他汀类药物是著名的降脂药物。他汀类药物的多效性作用对改善细胞治疗和组织工程方法的治疗效果产生了一些有益影响。在本综述中，讨论了他汀类药物对间充质干细胞行为的影响，包括分化、凋亡、增殖、迁移和血管生成，以及导致这些现象的分子途径。更好地理解他汀类药物介导的对间充质干细胞作用的途径和机制将为他汀类药物应用的扩展铺平道路。此外，由于需要设计一种合适的他汀类药物载体，以便在身体的理想部位维持足够剂量的活性他汀类药物，因此还综述了他汀类药物局部递送的不同系统。
