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小瓣环主动脉瓣狭窄患者行主动脉瓣新瓣叶形成术的中期结果

Midterm outcome of aortic valve neocuspidization for aortic valve stenosis with small annulus.

作者信息

Akiyama Sho, Iida Yasunori, Shimura Kazuma, Fujii Susumu, Shimizu Hideyuki, Sawa Shigeharu

机构信息

Department of Cardiovascular Surgery, Ogikubo Hospital, 3-1-24 Imagawa, Suginami-ku, Tokyo, 167-0035, Japan.

Department of Cardiovascular Surgery, Keio University, Tokyo, Japan.

出版信息

Gen Thorac Cardiovasc Surg. 2020 Aug;68(8):762-767. doi: 10.1007/s11748-020-01299-1. Epub 2020 Feb 1.

Abstract

OBJECTIVE

At our institution, we actively perform aortic valve neocuspidization (AVNeo) for aortic valve stenosis (AS) with a small annulus. In this report, we aimed to evaluate the midterm outcome of AVNeo for AS with a small annulus.

METHODS

From February 2011 to May 2017, we performed AVNeo for AS with a small annulus in 34 patients. Their mean age was 77.0 ± 9.1 years. Preoperative transthoracic echocardiography (TTE) revealed a mean peak pressure gradient average of 84.2 ± 31.1 mmHg. The effective orifice area index (EOAi) was 0.45 ± 0.14 cm/m. The mean annulus diameter was 18.4 ± 1.1 mm. Our procedure complies with the three cuspid suturing to the aortic annulus with glutaraldehyde-treated autologous pericardium.

RESULTS

There were no conversion to aortic valve replacement and no concomitant annulus enlargement. There were two inhospital mortalities resulting from a noncardiac cause. Three patients underwent reoperation owing to aortic regurgitation (n = 2) and infective endocarditis (n = 1). One patient underwent a pacemaker implantation for complete atrioventricular block. The mean follow-up period was 28.0 ± 22.7 months. Postoperative TTE showed a mean peak pressure gradient average of 18.3 ± 9.4 mmHg and a calculated mean EOAi of 1.18 ± 0.35 cm/m. The freedom from reoperation rates were 94.1% and 90.8% at 1 year and 5 years of follow-up, respectively. The overall survival rates were 91.2% and 76.8% at 1 and 5 years of follow-up, respectively.

CONCLUSIONS

The midterm outcome of AVNeo for AS with a small annulus was excellent. The long-term outcome and reliability of this procedure must be fully clarified.

摘要

目的

在我们机构,对于小瓣环的主动脉瓣狭窄(AS)患者,我们积极开展主动脉瓣新瓣叶形成术(AVNeo)。在本报告中,我们旨在评估AVNeo治疗小瓣环AS的中期结果。

方法

2011年2月至2017年5月,我们对34例小瓣环AS患者实施了AVNeo。他们的平均年龄为77.0±9.1岁。术前经胸超声心动图(TTE)显示平均峰值压力阶差为84.2±31.1mmHg。有效瓣口面积指数(EOAi)为0.45±0.14cm/m²。平均瓣环直径为18.4±1.1mm。我们的手术操作是采用经戊二醛处理的自体心包将三个瓣叶缝合至主动脉瓣环。

结果

无转为主动脉瓣置换的情况,也未同期进行瓣环扩大术。有2例患者因非心脏原因在住院期间死亡。3例患者因主动脉瓣反流(n = 2)和感染性心内膜炎(n = 1)接受了再次手术。1例患者因完全性房室传导阻滞接受了起搏器植入术。平均随访时间为28.0±22.7个月。术后TTE显示平均峰值压力阶差为18.3±9.4mmHg,计算得出的平均EOAi为1.18±0.35cm/m²。随访1年和5年时再次手术的免手术率分别为94.1%和90.8%。随访1年和5年时的总生存率分别为91.2%和76.8%。

结论

AVNeo治疗小瓣环AS的中期结果良好。该手术的长期结果和可靠性仍需充分阐明。

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