From the Scientific Research Institute of Epidemiology, Microbiology and Infectious Diseases, Tashkent, Uzbekistan.
Exp Clin Transplant. 2020 Jan;18(Suppl 1):47-50. doi: 10.6002/ect.TOND-TDTD2019.O23.
We investigated the clinical, epidemiologic, and pathogenetic features of viral hepatitis C in hemodialysis departments.
This multicenter study included patients who were seen at the hemodialysis department in Tashkent, Uzbekistan and at regional departments located in the Republic of Uzbekistan. We examined 395 patients who were on hemodialysis from 3 to 15 years. A diagnosis of chronic viral hepatitis C was made on the basis of anamnesis, clinical laboratory data, and detection of immunoglobulin G antibodies for hepatitis C virus.
From clinical and laboratory results analyzed in 395 patients, markers of infection with parenteral viral infections were shown in 181 patients (45.8%). Chronic viral hepatitis C had the highest incidence among infections, which was detected in 125 patients (31.6%). With regard to chronic renal failure, 11 patients (34%) with chronic viral hepatitis C had a transient form of chronic renal hepatic failure with development of adverse outcomes. Of patients with chronic viral hepatis C infection, 13 patients (40%) with hemorrhagic syndrome developed progressive anemia and 8 patients (25%) developed persistent polyserositis in the form of hydrothorax, ascites, and pericarditis. These developments reflect the aggravating effects of chronic viral hepatitis C on the course of chronic renal failure.
In our study that included patients seen at hemodialysis departments in Uzbekistan, chronic viral hepatitis C was greatly prevalent, although occurring mainly in a minimal form of the pathologic process. Chronic viral hepatitis C has an aggravating effect on the course of underlying diseases with development of adverse outcomes.
我们研究了血液透析科丙型病毒性肝炎的临床、流行病学和发病机制特征。
这项多中心研究包括在乌兹别克斯坦塔什干血液透析科和乌兹别克斯坦共和国各地区部门就诊的患者。我们检查了 395 名透析 3 至 15 年的患者。慢性丙型病毒性肝炎的诊断基于病史、临床实验室数据和丙型肝炎病毒免疫球蛋白 G 抗体的检测。
从 395 名患者的临床和实验室结果分析中，181 名患者（45.8%）显示出与经肠道感染相关的标志物。慢性丙型病毒性肝炎在感染中发病率最高，共发现 125 例（31.6%）。在慢性肾衰竭方面，11 例（34%）慢性丙型病毒性肝炎患者出现短暂性慢性肝肾功能衰竭，伴有不良结局。在慢性丙型肝炎病毒感染者中，13 例（40%）出血综合征患者出现进行性贫血，8 例（25%）患者出现胸腔积液、腹水和心包炎等持续性多浆膜炎。这些发展反映了慢性丙型病毒性肝炎对慢性肾衰竭病程的加重作用。
在我们包括乌兹别克斯坦血液透析科患者的研究中，慢性丙型病毒性肝炎发病率很高，尽管主要发生在轻微的病理过程中。慢性丙型病毒性肝炎对基础疾病的病程有加重作用，导致不良结局。
