Liu Xiaojin, Xu Wanbo, Liu Zhenhe, Ye Junli
Department of Pharmacy, Dezhou People's Hospital, 1751 XinHu Street, Dezhou, Shandong 253000, China.
Department of Radiology, Dezhou People's Hospital, 1751 XinHu Street, Dezhou, Shandong 253000, China.
Curr Med Imaging Rev. 2019;15(5):504-510. doi: 10.2174/1573405614666180807113422.
Intraductal papillary mucinous neoplasms (IPMNs) are among the important premalignant lesions. Early detection and intervention are critical to positive patient outcomes. Magnetic resonance imaging (MRI) can be used to evaluate the malignancy of IPMNs, and magnetic resonance cholangiopancreatography (MRCP) is recommended for follow-up of pancreatic cystic lesions.
To evaluate the diagnostic performance of MRI combined with MRCP in determining the malignant potential of pancreas IPMN.
This is a retrospective study of 55 patients with 58 pancreatic lesions confirmed after surgery, which were analyzed and divided into two groups, a benign IPMN group (n = 27) and a malignant IPMN group (n = 31). Two radiologists analyzed the high-risk stigmata and worrisome features of pancreas IPMN to evaluate the malignant potential. Score all the lesions as proposed by the international consensus guidelines 2012, and calculate the sensitivity, specificity and accuracy.
There were significant differences of size, enhancement of solid components, and degree of dilation of the main pancreatic duct between benign and malignant IPMN (P < 0.05). However, differences in gender, age and location of disease between the two groups were not statistically significant (P > 0.05). The sensitivity, specificity and accuracy of MRI combined with MRCP in preoperative diagnosis of malignant IPMNs were 90.3% (28/31), 70.4% (19/27) and 81.0% (47/58) respectively, when at least one worrisome feature was present.
MRI combined with MRCP is useful in the evaluation of the benign and malignant pancreas IPMN.
导管内乳头状黏液性肿瘤（IPMNs）是重要的癌前病变之一。早期发现和干预对患者的良好预后至关重要。磁共振成像（MRI）可用于评估IPMNs的恶性程度，磁共振胰胆管造影（MRCP）推荐用于胰腺囊性病变的随访。
评估MRI联合MRCP在判断胰腺IPMN恶性潜能方面的诊断性能。
这是一项对55例患者的58个胰腺病变进行的回顾性研究，这些病变经手术确诊，分析并分为两组，即良性IPMN组（n = 27）和恶性IPMN组（n = 31）。两名放射科医生分析胰腺IPMN的高危征象和可疑特征以评估其恶性潜能。按照2012年国际共识指南对所有病变进行评分，并计算敏感性、特异性和准确性。
良性和恶性IPMN在大小、实性成分强化及主胰管扩张程度方面存在显著差异（P < 0.05）。然而，两组在性别、年龄和病变位置方面的差异无统计学意义（P > 0.05）。当存在至少一个可疑特征时，MRI联合MRCP术前诊断恶性IPMN的敏感性、特异性和准确性分别为90.3%（28/31）、70.4%（19/27）和81.0%（47/58）。
MRI联合MRCP有助于评估胰腺IPMN的良恶性。
