Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Department of Psychiatry, Queen's University, 752 King Street West, Kingston, Ontario K7L 4X3, Canada; International Consortium for Research on Mood & Psychotic Disorders, McLean Hospital, Belmont, MA, USA.
Psychiatr Clin North Am. 2020 Mar;43(1):167-186. doi: 10.1016/j.psc.2019.10.015. Epub 2019 Dec 3.
Despite the relatively high prevalence of mixed symptoms and features among patients with mood disorders, the current literature supporting the specific efficacy of second-generation antipsychotics and mood stabilizers for the treatment of mixed symptoms is limited. Several studies have demonstrated that acute affective episodes with mixed symptoms or features tend to respond unsatisfactory to treatments that are usually more effective for the management of other affective phases. There is clearly a need for clinical trials in order to determine the more adequate pharmacologic option for the treatment of individuals suffering from affective episodes with mixed features.
尽管心境障碍患者中混合症状和特征的患病率相对较高，但目前支持第二代抗精神病药和心境稳定剂治疗混合症状的具体疗效的文献有限。几项研究表明，伴有混合症状或特征的急性情感发作对通常对其他情感阶段更有效的治疗反应往往不理想。显然需要进行临床试验，以确定更适合治疗伴有混合特征的情感发作个体的药物选择。
