International Consortium for Research on Mood & Psychotic Disorders, McLean Hospital, Belmont, MA, USA; Mailman Research Center 3, McLean Hospital, 115 Mill Street, Belmont, MA 02478-9106, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Lucio Bini Mood Disorders Center, Cagliari, Italy.
International Consortium for Research on Mood & Psychotic Disorders, McLean Hospital, Belmont, MA, USA; Mailman Research Center 3, McLean Hospital, 115 Mill Street, Belmont, MA 02478-9106, USA; Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.
Psychiatr Clin North Am. 2020 Mar;43(1):83-93. doi: 10.1016/j.psc.2019.10.008. Epub 2019 Nov 27.
Mixed features of the opposite nominal mood-polarity are increasingly recognized in both depressive and [hypo]manic phases of major affective disorders. They are associated with major increases of risk of suicidal behaviors. The authors reviewed the association of suicidal behavior with mixed features in both major depressive and bipolar disorders, as well as potentially relevant adverse effects of antidepressant treatment and use of alternative treatments aimed at minimizing agitation and suicidal risk.
在重性情感障碍的抑郁和[轻]躁狂相中，越来越多地认识到对立的名词语气极性的混合特征。它们与自杀行为风险的显著增加相关。作者回顾了自杀行为与重性抑郁障碍和双相障碍中的混合特征之间的关联，以及抗抑郁治疗和使用旨在最小化激越和自杀风险的替代治疗方法的潜在相关不良效应。
