Petit Thierry
Service d'oncologie médicale, Centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 30042, 67065 Strasbourg Cedex, France.
Bull Cancer. 2019 Dec;106(12S1):S24-S27. doi: 10.1016/S0007-4551(20)30044-8.
For young patients with hormone receptor-positive early breast cancer, tamoxifen for at least 5 years is the standard endocrine treatment. Prolonged endocrine treatment over 5 years is recommended for patients with high risk of late relapse. When adjuvant chemotherapy is indicated, prolonged iatrogenic amenorrhea is a strong pronostic factor. WIthout persistant amenorrhea after chemotherapy, it is indicated to associate ovarian suppression to the endocrine treatment. Optimal duration of this induced amenorrhea is unknown.