Matsumoto Kenji, Kobayashi Yoshinori, Hirokane Tsukasa, Yoshida Masahiro
Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
Chem Pharm Bull (Tokyo). 2020;68(2):167-172. doi: 10.1248/cpb.c19-00947.
A heterogeneous metal catalyst enabled the intramolecular oxidative coupling of diarylamines to form carbazoles with molecular oxygen as the sole oxidant. Rh/C had efficient catalytic activity and allowed the catalyst loading to be reduced to 0.1 mol% while maintaining excellent yields of carbazoles. This reaction is operationally simple in an open-to-air setup, and provides a green and atom-economical process for an efficient synthetic approach to N-substituted carbazoles.
一种多相金属催化剂能够实现二芳基胺的分子内氧化偶联反应，以分子氧作为唯一氧化剂生成咔唑。Rh/C具有高效的催化活性，可将催化剂负载量降低至0.1 mol%，同时保持咔唑的优异产率。该反应在开放式空气中操作简单，为N-取代咔唑的高效合成提供了一种绿色且原子经济的方法。
