Makhani Naila
, New Haven, CT, USA.
Curr Treat Options Neurol. 2020 Feb 3;22(1):3. doi: 10.1007/s11940-020-0608-8.
This review provides the reader with updated information needed to make an accurate diagnosis of radiologically isolated syndrome (RIS), discusses controversies and considerations related to therapeutic intervention in RIS, and summarizes ongoing clinical intervention trials.
Individuals with RIS lack clinical neurological symptoms but are at risk for the subsequent development of a first clinical neurological event consistent with a diagnosis of multiple sclerosis. There are two ongoing clinical intervention trials to determine whether disease-modifying treatments for multiple sclerosis can delay or prevent a first clinical event in individuals with RIS. If clinical trials demonstrate a beneficial effect of disease-modifying therapy, such interventions should be considered in individuals with RIS.
本综述为读者提供准确诊断放射学孤立综合征（RIS）所需的最新信息，讨论与RIS治疗干预相关的争议和注意事项，并总结正在进行的临床干预试验。
患有RIS的个体缺乏临床神经症状，但有随后发生符合多发性硬化症诊断的首次临床神经事件的风险。有两项正在进行的临床干预试验，以确定用于治疗多发性硬化症的疾病修正疗法是否可以延迟或预防RIS个体发生首次临床事件。如果临床试验证明疾病修正疗法有有益效果，则应考虑对RIS个体进行此类干预。
