Demas C P, Vann R, Ritter E, Sepka R S, Klitzman B, Barwick W J
Division of Plastic and Reconstructive Surgery, Duke University Medical Center, Durham, N.C.
Plast Reconstr Surg. 1988 Dec;82(6):1042-5. doi: 10.1097/00006534-198812000-00016.
The high rate of thrombosis of 1.0-mm polytetrafluoroethylene (PTFE) grafts has limited their use in microvascular surgery. One possible reason for this is the blood-gas interface due to entrapped air in the interstices. The present study examines the effect on patency rates of elimination of this blood-gas interface by high pressurization. Comparing pressurized and nonpressurized grafts in the same animals showed a patency rate of 100 percent at 7 days for treated grafts, while the control (nonpressurized) grafts had all clotted by 1 hour. The implications for microvascular surgery as well as vascular surgery in general are discussed.
1.0毫米的聚四氟乙烯（PTFE）移植物的高血栓形成率限制了它们在微血管手术中的应用。造成这种情况的一个可能原因是由于孔隙中截留的空气形成的血气界面。本研究探讨了通过高压消除这种血气界面对通畅率的影响。在同一动物中比较加压和未加压的移植物，结果显示，经过处理的移植物在7天时通畅率为100%，而对照（未加压）移植物在1小时内全部形成血栓。本文还讨论了这一研究结果对微血管手术以及一般血管手术的意义。
