Matsutomo Toshiaki
Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Akitakata-shi, Hiroshima 739-1195, Japan.
Exp Ther Med. 2020 Feb;19(2):1479-1484. doi: 10.3892/etm.2019.8375. Epub 2019 Dec 27.
Elevated blood pressure is a major risk factor for cardiovascular diseases. Although some effective drug treatments are available, a relatively large proportion of patients have uncontrolled blood pressure. Dietary supplements are used for the prevention and treatment of hypertension as complementary and alternative medicines. Of the various dietary supplements, antioxidants, fish oil and diverse herbal products are commonly used. Within this context, it is important to determine the actual effectiveness and possible side-effects of these supplements; however, some of the products have been poorly investigated for their effects and safety. In the current review, we focus on garlic and several other dietary supplements, such as coenzyme Q10, fish oil and probiotics, that have exhibited significant beneficial effects on blood pressure in clinical trials. In addition, we discuss the possible mechanisms of action responsible for their anti-hypertensive effects, as well as the safety, active ingredients and their potential use as adjunct therapies for uncontrolled hypertension.
血压升高是心血管疾病的主要危险因素。尽管有一些有效的药物治疗方法，但仍有相当大比例的患者血压控制不佳。膳食补充剂作为补充和替代药物用于高血压的预防和治疗。在各种膳食补充剂中，抗氧化剂、鱼油和各种草药产品常用。在此背景下，确定这些补充剂的实际疗效和可能的副作用很重要；然而，其中一些产品的效果和安全性研究不足。在当前的综述中，我们重点关注大蒜以及其他几种膳食补充剂，如辅酶Q10、鱼油和益生菌，这些在临床试验中已显示出对血压有显著有益作用。此外，我们讨论了其降压作用的可能作用机制，以及安全性、活性成分及其作为未控制高血压辅助治疗的潜在用途。
