生长抑素类似物治疗大细胞转移性胰腺神经内分泌癌——病例报告及文献综述
LARGE CELL METASTATIC PANCREATIC NEUROENDOCRINE CARCINOMA TREATED WITH SOMATOSTATIN ANALOGUES - CASE REPORT AND LITERATURE REVIEW.
作者信息
Croitoru A, Dinu I, Herlea V, Becheanu G, Grasu M, Lupescu I, Dima S O, Buica F, Dumitrascu T, Lungulescu C, Croitoru V M, Tanase A, Negru S M, Gramaticu I M
机构信息
Fundeni Clinical Institute - Department of Medical Oncology, Bucharest, Romania.
"Titu Maiorescu" University, Faculty of Medicine, Bucharest, Romania.
出版信息
Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):390-397. doi: 10.4183/aeb.2019.390.
UNLABELLED
We report the case of a 55-year-old-male with a large cell metastatic pancreatic neuroendocrine carcinoma treated for 14 months with lanreotide autogel having a stable disease (SD) and not responding to chemotherapy. The somatostatin analogues (SSA) were introduced after an episode of diarrhea and controlled the disease. Progression-free survival (PFS) as determined by Computerized Tomography (CT) scans was obtained for 14 months. After more than a year, the patient's health state deteriorated along with progressive disease. The capecitabine-temozolomide regimen was challenged, but after three cycles, a rapid clinical decline was noted.
CONCLUSION
This unexpected event (diarrhea) in the course of the disease could represent the beginning of carcinoid syndrome. While the lanreotide autogel helped the episode of diarrhea pass, it also helped gain control over the disease itself.
未标注
我们报告了一例55岁男性，患有大细胞转移性胰腺神经内分泌癌，接受兰瑞肽长效凝胶治疗14个月，病情稳定（SD）且对化疗无反应。在出现一次腹泻后开始使用生长抑素类似物（SSA），并控制了病情。通过计算机断层扫描（CT）扫描确定的无进展生存期（PFS）为14个月。一年多后，患者的健康状况随着疾病进展而恶化。尝试了卡培他滨 - 替莫唑胺方案，但三个周期后，临床症状迅速恶化。
结论
疾病过程中这一意外事件（腹泻）可能代表类癌综合征的开始。兰瑞肽长效凝胶不仅帮助腹泻症状缓解，还有助于控制疾病本身。
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