磷酸酶和张力蛋白同源物缺失在乳腺癌中的预后意义
The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer.
作者信息
Windarti Indri, Harahap Wirsma Arif, Nindrea Ricvan Dana, Yerizel Eti, Rustamadji Primariadewi
机构信息
Faculty of Medicine, Andalas University, Padang, Indonesia.
Department of Surgical, Oncology Division, Faculty of Medicine, Andalas University, Dr M Djamil General Hospital, Padang, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 Oct 15;7(21):3716-3720. doi: 10.3889/oamjms.2019.757. eCollection 2019 Nov 15.
AIM
This study aims to determine the prognostic significance of phosphatase and tensin homolog (PTEN) loss in breast cancer.
METHODS
We conducted a meta-analysis study. Sample of this study were research articles that evaluated PTEN loss and prognosis in breast cancer patients. We searched for relevant studies published in PubMed and Proquest from January 2010 to July 2018. We reviewed studies that examined the association between immunohistochemical expression of PTEN and breast cancer prognosis using meta-analysis methods. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3).
RESULTS
There were 7 studies conducted a systematic review then continued to evaluate the association of PTEN loss and breast cancer prognosis by meta-analysis. There was a significant association of PTEN loss with poor prognosis of breast cancer (RR = 0.76 [95% CI 0.59-0.98 p <0.07), and there was not any significant publication bias for studies included.
CONCLUSION
This study confirmed PTEN loss is an important independent factor for breast cancer prognosis.
目的
本研究旨在确定磷酸酶和张力蛋白同源物（PTEN）缺失在乳腺癌中的预后意义。
方法
我们进行了一项荟萃分析研究。本研究的样本是评估乳腺癌患者PTEN缺失与预后的研究文章。我们检索了2010年1月至2018年7月在PubMed和Proquest上发表的相关研究。我们使用荟萃分析方法回顾了研究PTEN免疫组化表达与乳腺癌预后之间关联的研究。使用固定效应模型和随机效应模型计算合并风险比（RR）。数据使用Review Manager 5.3（RevMan 5.3）进行处理。
结果
有7项研究进行了系统评价，然后通过荟萃分析继续评估PTEN缺失与乳腺癌预后的关联。PTEN缺失与乳腺癌预后不良存在显著关联（RR = 0.76 [95% CI 0.59 - 0.98，p < 0.07]），并且纳入的研究没有任何显著的发表偏倚。
结论
本研究证实PTEN缺失是乳腺癌预后的一个重要独立因素。
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