Nindrea Ricvan Dana, Aryandono Teguh, Lazuardi Lutfan, Dwiprahasto Iwan
Doctoral Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Public Health, Faculty of Medicine, Universitas Andalas, Padang, Indonesia.
Iran J Public Health. 2019 Feb;48(2):198-205.
Breast cancer is the most common cancer type in women not only in world but also in Malays ethnicity between Malaysia and Indonesia. Breast cancer has varying incidence in every country, but genetic factor by family history influence the incidence of breast cancer. This systematic review and meta-analysis was performed to determine family history of breast cancer and breast cancer risk between Malays ethnicity in Malaysia and Indonesia.
This meta-analysis was conducted on published research articles on family history of breast cancer and breast cancer risk between Malays ethnicity in Malaysia and Indonesia published between Jan 1999 and Jul 2018 in the online article databases of PubMed, ProQuest and EBSCO. Pooled odds ratios (OR) were calculated with fixed and random-effect models. Publication bias was visually evaluated by using funnel plots and statistically assessed through Egger's and Begg's tests. Data were processed using Review Manager 5.3 (RevMan 5.3) and Stata version 14.2 (Stata Corporation).
We reviewed 1123 articles. There are 10 studies with number of samples 4511 conducted a systematic review and continued with Meta-analysis of relevant data. The results showed significant association between family history of breast cancer with breast cancer risk in Malays ethnicity in Malaysia and Indonesia (OR = 3.34 [95% CI 2.68-4.15, <0.00001]). There was not significant publication bias for studies included in family history of breast cancer and breast cancer risk in Malays ethnicity in Malaysia and Indonesia.
This analysis confirmed the association of family history of breast cancer and breast cancer risk between Malays ethnicity in Malaysia and Indonesia.
乳腺癌不仅是全球女性中最常见的癌症类型，在马来西亚和印度尼西亚的马来族裔女性中亦是如此。每个国家的乳腺癌发病率各不相同，但家族史中的遗传因素会影响乳腺癌的发病率。本系统评价和荟萃分析旨在确定马来西亚和印度尼西亚马来族裔中乳腺癌家族史与乳腺癌风险之间的关系。
本荟萃分析针对1999年1月至2018年7月期间发表在PubMed、ProQuest和EBSCO在线文章数据库中有关马来西亚和印度尼西亚马来族裔乳腺癌家族史与乳腺癌风险的已发表研究文章进行。采用固定效应模型和随机效应模型计算合并比值比（OR）。通过漏斗图直观评估发表偏倚，并通过Egger检验和Begg检验进行统计学评估。数据使用Review Manager 5.3（RevMan 5.3）和Stata 14.2版本（Stata公司）进行处理。
我们检索了1123篇文章。有10项研究，样本量为4511，进行了系统评价并继续对相关数据进行荟萃分析。结果显示，在马来西亚和印度尼西亚的马来族裔中，乳腺癌家族史与乳腺癌风险之间存在显著关联（OR = 3.34 [95% CI 2.68 - 4.15, <0.00001]）。在马来西亚和印度尼西亚马来族裔乳腺癌家族史与乳腺癌风险的研究中，纳入的研究没有显著的发表偏倚。
本分析证实了马来西亚和印度尼西亚马来族裔中乳腺癌家族史与乳腺癌风险之间的关联。
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