维生素B12和叶酸成功治疗异维A酸引起的肌肉骨骼疼痛
Successful Treatment of Isotretinoin Induced Musculoskeletal Pain by Vitamin B12 and Folic Acid.
作者信息
Feily Amir
机构信息
Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Open Access Maced J Med Sci. 2019 Oct 10;7(21):3726-3727. doi: 10.3889/oamjms.2019.799. eCollection 2019 Nov 15.
BACKGROUND
Daily supplementation with vitamin B12 and folate, which are the cofactors of the enzymatic reactions involved in Hcy metabolism, can lower plasma levels of Hcy and prevent osteoporosis induced by retinoid.
CASE PRESENTATION
We reported six patients with nodulocystic acne who reported musculoskeletal pain after taking isotretinoin which successfully treated with daily supplementation of folic acid and B12.
CONCLUSION
We suggest our colleagues consider these supplements when a patient suffers from musculoskeletal pain following starting isotretinoin and continue the treatment as well. In the end, the authors concluded that robust trials with more patients are needed to establish the efficacy of Vit B12 and folic acid in the treatment of isotretinoin induced musculoskeletal pain.
背景
每日补充维生素B12和叶酸，它们是同型半胱氨酸（Hcy）代谢中酶促反应的辅助因子，可降低血浆Hcy水平，并预防维甲酸诱导的骨质疏松症。
病例报告
我们报告了6例结节囊肿性痤疮患者，他们在服用异维A酸后出现肌肉骨骼疼痛，通过每日补充叶酸和维生素B12成功治愈。
结论
我们建议同事们，当患者在开始服用异维A酸后出现肌肉骨骼疼痛时，考虑使用这些补充剂并继续治疗。最后，作者得出结论，需要更多患者参与的有力试验来确定维生素B12和叶酸治疗异维A酸诱导的肌肉骨骼疼痛的疗效。
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