Li Weiguang, Duan Ying, Yan Jiaqing, Gao He, Li Xiaoli
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
2Clinical Sleep Medical Center, Air Force Medical Center, PLA, Beijing 100036, China.
Aging Dis. 2020 Feb 1;11(1):73-81. doi: 10.14336/AD.2019.0420. eCollection 2020 Feb.
Sleep spindles (SS) and K-complexes (KC) play important roles in human sleep. It has been reported that age, body mass index (BMI), and apnea-hypopnea index (AHI) may influence the number of SS or KC in non-rapid-eye-movement (NREM) 2 (N2) sleep. In this study, we investigated whether the loss of SS or KC is associated with the above factors in NREM 3 (N3) sleep. A total of 152 cases were enrolled from 2013 to 2017. The correlations between the number of SS or KC in N3 sleep and participants' characteristics were analyzed using Spearman rank correlation. Chi-squared test was used to assess the effects of age, sleep efficiency, and BMI on the loss of N3 sleep, N3 spindle and N3 KC. Our results showed that there were negative correlations between the number of SS in N3 sleep with age, BMI, and AHI ( < 0.001), and similar trends were found for KC as well. The loss of SS and KC in N3 sleep was related with age, BMI, and AHI ( < 0.01), as was the loss of N3 sleep ( < 0.01). However, sleep efficiency was not related with the loss of N3 sleep, SS and KC in N3 sleep ( > 0.05). The present study supports that age, BMI, and AHI are all influencing factors of SS and KC loss in human N3 sleep, but sleep efficiency was not an influencing factor in the loss of N3 sleep and the loss of SS and KC in N3 sleep.
睡眠纺锤波（SS）和K复合波（KC）在人类睡眠中发挥着重要作用。据报道，年龄、体重指数（BMI）和呼吸暂停低通气指数（AHI）可能会影响非快速眼动（NREM）2期（N2）睡眠中SS或KC的数量。在本研究中，我们调查了NREM 3期（N3）睡眠中SS或KC的缺失是否与上述因素相关。2013年至2017年共纳入152例患者。使用Spearman等级相关分析N3睡眠中SS或KC数量与参与者特征之间的相关性。采用卡方检验评估年龄、睡眠效率和BMI对N3睡眠缺失、N3纺锤波和N3 KC缺失的影响。我们的结果显示，N3睡眠中SS的数量与年龄、BMI和AHI呈负相关（<0.001），KC也有类似趋势。N3睡眠中SS和KC的缺失与年龄、BMI和AHI相关（<0.01），N3睡眠的缺失也相关（<0.01）。然而，睡眠效率与N3睡眠的缺失、N3睡眠中SS和KC的缺失无关（>0.05）。本研究支持年龄、BMI和AHI均为人类N3睡眠中SS和KC缺失的影响因素，但睡眠效率不是N3睡眠缺失以及N3睡眠中SS和KC缺失的影响因素。
