Sun Lin, Zhang Xiangmin, Huang Shaoxiong, Liang Jiuxing, Luo Yuxi
School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, China.
Sleep-Disordered Breathing Center of the 6th Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Respir Physiol Neurobiol. 2018 Jan;248:10-16. doi: 10.1016/j.resp.2017.11.004. Epub 2017 Nov 9.
This study characterized the differences in K-complex (KC) morphology features between obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and healthy controls and analyzed the effect of respiratory events on KC morphology. We enrolled 42 male subjects (21 OSAHS patients and 21 age-matched healthy controls) who underwent overnight polysomnography. KCs in stage N2 were manually identified. We found that KCs in healthy controls had larger negative and whole amplitudes, longer durations, and smoother positive waves than OSAHS patients but smaller positive amplitudes. Most features showed highly significant differences after Bonferroni correction (p<0.001/3). After separating out the KCs associated with respiratory events in OSAHS patients, the differences between the groups remained but were relatively smaller. In OSAHS patients, compared with the spontaneous KCs not evoked by obvious factors, the KCs occurring after respiratory events had larger amplitudes, steeper slopes, larger negative wave amplitude and duration ratios. KCs occurring during respiratory events showed lower amplitudes and shorter durations. These results may reveal the impact of respiratory events on sleep and brain function.
本研究对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者与健康对照者的K复合波（KC）形态特征差异进行了表征，并分析了呼吸事件对KC形态的影响。我们纳入了42名男性受试者（21名OSAHS患者和21名年龄匹配的健康对照者），他们均接受了整夜多导睡眠图检查。手动识别N2期的KC。我们发现，与OSAHS患者相比，健康对照者的KC具有更大的负向和整体波幅、更长的持续时间以及更平滑的正向波，但正向波幅较小。在Bonferroni校正后，大多数特征显示出高度显著的差异（p<0.001/3）。在分离出OSAHS患者中与呼吸事件相关的KC后，两组之间的差异仍然存在，但相对较小。在OSAHS患者中，与无明显因素诱发的自发KC相比，呼吸事件后出现的KC具有更大的波幅、更陡的斜率、更大的负向波幅和持续时间比。呼吸事件期间出现的KC波幅较低且持续时间较短。这些结果可能揭示了呼吸事件对睡眠和脑功能的影响。
