[Chromosome analysis of ovocytes and human embryos collected after fertilization in vitro. A model of natural selection against aneuploidy].
作者信息
Plachot M, De Grouchy J, Junca A M, Mandelbaum J, Cohen J, Salat-Baroux J
机构信息
INSERM U.173, UA 119 CNRS, Laboratoire de Cytogénétique Humaine et Comparée, Hôpital Necker Enfants-Malades, Paris.
出版信息
Rev Fr Gynecol Obstet. 1988 Oct;83(10):613-7.
PMID:3201050
Abstract
Fertilization in-vitro offers the possibility of studying the karyotype of ovocytes obtained after superovulation, when they are not fertilized. Among 120 ovocytes, 30 p. cent presented a chromosomal anomaly. The same study was carried out on morphologically normal or abnormal embryos - and the percentage of chromosomal anomalies approximates here 27 p. cent. These studies offer a model of natural selection against chromosomal anomalies and confirm the limiting role of these anomalies in the success of FIV.
摘要
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