Helleman P W, Bartels P C, van Waveren Hogervorst G D
Department of Haematology, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands.
Scand J Clin Lab Invest. 1988 Nov;48(7):697-704.
The red cell distribution width (RDW) calculated from the data of an erythrocyte size distribution (ESD) histogram generated by a Technicon H6000/H601 blood cell analyser was shown to be not suitable for distinguishing iron deficiency from thalassaemia trait and other microcytic conditions. The absolute distribution width at half maximum (ADW0.5) of these ESD histograms can be used efficiently for screening on thalassaemia trait. The ADW0.5 values appeared to be more powerful for detecting alpha thalassaemia and beta thalassaemia trait than the decision algorithms described earlier. A decreased MCV combined with a small ADW0.5 offers an indication of thalassaemia trait, the diagnosis being later confirmed by more definitive methods. By utilizing the ADW0.5, the number of subjects with thalassaemia trait, particularly those with alpha thalassaemia, detected in the south of The Netherlands was highly increased.
由Technicon H6000/H601血细胞分析仪生成的红细胞大小分布（ESD）直方图数据计算得出的红细胞分布宽度（RDW），并不适合用于区分缺铁性贫血与地中海贫血特征以及其他小细胞性病症。这些ESD直方图的半峰绝对分布宽度（ADW0.5）可有效地用于地中海贫血特征的筛查。ADW0.5值在检测α地中海贫血和β地中海贫血特征方面似乎比先前描述的判定算法更有效。MCV降低并伴有较小的ADW0.5提示地中海贫血特征，随后通过更确切的方法确诊。通过利用ADW0.5，在荷兰南部检测出的具有地中海贫血特征的受试者数量，尤其是那些患有α地中海贫血的受试者数量大幅增加。
