Dutka R, Chmyr N, Svitlyk H, Leontieva Z
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
Georgian Med News. 2019 Dec(297):80-83.
The study focuses on the levels of prolactin, cortisol, free thyroxine (fT4) and thyroid-stimulating hormone (TSH) as markers of Metabolic Syndrome (MS) which is a risk factor for Coronary Artery Disease (CAD) and type 2 Diabetes Mellitus (DM). 245 patients were examined and divided into 4 groups: 82 patients with MS in the first group; 44 patients with МS complicated by CAD in the second group; 44 patients with CAD and compensated type 2 DM which developed as a result of МS in the third group; 75 patients with decompensated type 2 DM in the fourth group. The control group consisted of 40 healthy individuals. All patients were diagnosed with class ІІ and ІІІ obesity. Then, the levels of prolactin, cortisol, free thyroxinе (fT4) and thyroid-stimulating hormone (TSH) were measured. According to the results of the research, significantly increased levels of cortisol, thyroid-stimulating hormone (TSH) and prolactin in women are observed in the first group. The second group is characterized by the normal levels of cortisol and prolactin in women, although the level of thyroid-stimulating hormone (TSH) is significantly increased. The levels of the above-mentioned hormones are not different in patients of the third group compared to the results of the second group. Meanwhile, the cortisol and prolactin levels increase significantly in the fourth group compared with the control group. However, the level of thyroid-stimulating hormone (TSH) is within the normal range. The level of free thyroxine is within the normal range in all groups. Thus, the examined markers represent the pathogenetic and clinical features of the MS course, especially on condition that a patient suffers from CAD and type 2 DM. Furthermore, the examined markers have diagnostic and prognostic significance.
该研究聚焦于催乳素、皮质醇、游离甲状腺素（fT4）和促甲状腺激素（TSH）水平，将其作为代谢综合征（MS）的标志物，而代谢综合征是冠状动脉疾病（CAD）和2型糖尿病（DM）的危险因素。对245名患者进行了检查，并将其分为4组：第一组82名患有MS的患者；第二组44名患有合并CAD的MS患者；第三组44名患有因MS导致的CAD和代偿性2型DM的患者；第四组75名患有失代偿性2型DM的患者。对照组由40名健康个体组成。所有患者均被诊断为Ⅱ级和Ⅲ级肥胖。然后，测量了催乳素、皮质醇、游离甲状腺素（fT4）和促甲状腺激素（TSH）水平。根据研究结果，在第一组中观察到女性的皮质醇、促甲状腺激素（TSH）和催乳素水平显著升高。第二组女性的皮质醇和催乳素水平正常，尽管促甲状腺激素（TSH）水平显著升高。与第二组结果相比，第三组患者上述激素水平无差异。同时，与对照组相比，第四组的皮质醇和催乳素水平显著升高。然而，促甲状腺激素（TSH）水平在正常范围内。所有组的游离甲状腺素水平均在正常范围内。因此，所检测的标志物代表了MS病程的发病机制和临床特征，尤其是在患者患有CAD和2型DM的情况下。此外，所检测的标志物具有诊断和预后意义。
