Chen Yangjing, Li Yanzi, Liu Jianlin, Yang Lin
Department of Otolaryngology.
Department of Medical Administration.
Medicine (Baltimore). 2020 Jan;99(3):e18824. doi: 10.1097/MD.0000000000018824.
This study aims to investigate the clinical characteristics and outcomes of carotid body tumors in Chinese patients in the last decade. A systematic search was conducted without limits and included studies published between January 2006 and December 2016 according to PubMed, the Chinese Science Citation Database, the China Science Periodical Database and the China National Knowledge Infrastructure. Relevant synonyms for the search terms "paraganglioma" and "carotid body tumor" were applied, and the clinical data were evaluated and analyzed. There were 1810 cases of CBTs reported in the last decade, of which females accounted for 60.22%, and the mean age was 40.60 years, with most cases being sporadic (98.51%). Surgical resection was performed in 1791 cases: vessel repair occurred in 38.88% of the cases, carotid ligation occurred in 1.42% of the cases, and 1.05% of the patients refused treatment. Some patients underwent selective embolization, and the results showed that embolization could decrease procedure time and blood loss (P < .01). Stroke and death occurred in 1.95% and 0.39% of patients, respectively. Malignant CBTs accounted for 4.30% of cases, and the metastatic sites involved were local metastasis (46.88%), lung (31.25%), bone (21.88%), liver (12.50%), and brain (9.38%). The overall survival rate was 98.87% 36 months after the procedure, and the survival rate of metastatic cases was 56.25% 6 months after recurrence; however, only 21.88% of metastatic cases received radiotherapy. The CBTs of Chinese patients showed some clinical features that were different from those of Western patients.
本研究旨在调查近十年来中国患者颈动脉体瘤的临床特征及预后。进行了无限制的系统检索，纳入了2006年1月至2016年12月期间发表在PubMed、中国科学引文数据库、中国科技期刊数据库和中国知网的研究。应用了搜索词“副神经节瘤”和“颈动脉体瘤”的相关同义词，并对临床数据进行了评估和分析。近十年来共报告了1810例颈动脉体瘤病例其中女性占60.22%，平均年龄为40.60岁，大多数病例为散发性（98.51%）。1791例患者接受了手术切除：38.88%的病例进行了血管修复，1.42%的病例进行了颈动脉结扎，1.05%的患者拒绝治疗。部分患者接受了选择性栓塞，结果显示栓塞可减少手术时间和失血量（P<0.01）。中风和死亡分别发生在1.95%和0.39%的患者中。恶性颈动脉体瘤占病例的4.30%，转移部位包括局部转移（46.88%）、肺（31.25%）、骨（21.88%）、肝（12.50%）和脑（9.38%）。术后36个月总生存率为98.87%，转移病例复发后6个月生存率为56.25%；然而，只有21.88%的转移病例接受了放疗。中国患者的颈动脉体瘤表现出一些与西方患者不同的临床特征。
