Birgin Emrullah, Rasbach Erik, Seyfried Steffen, Rathmann Nils, Diehl Steffen J, Schoenberg Stefan O, Reissfelder Christoph, Rahbari Nuh N
Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Institute of Clinical Radiology and Nuclear Medicine, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Cancers (Basel). 2020 Jan 27;12(2):294. doi: 10.3390/cancers12020294.
Radioembolization with Y-microspheres has been reported to induce contralateral liver hypertrophy with simultaneous ipsilateral control of tumor growth. The aim of the present systematic review was to summarize the evidence of contralateral liver hypertrophy and oncological outcome following unilateral treatment with radioembolization. A systematic literature search using the MEDLINE, EMBASE, and Cochrane libraries for studies published between 2008 and 2020 was performed. A total of 16 studies, comprising 602 patients, were included. The median kinetic growth rate per week of the contralateral liver lobe was 0.7% and declined slightly over time. The local tumor control was 84%. Surgical resection after radioembolization was carried out in 109 out of 362 patients (30%). Although the available data suggest that radioembolization prior to major hepatectomy is safe with a promising oncological outcome, the definitive role of radioembolization requires assessment within controlled clinical trials.
据报道，使用钇微球进行放射性栓塞可诱导对侧肝叶肥大，同时同侧肿瘤生长得到控制。本系统评价的目的是总结放射性栓塞单侧治疗后对侧肝叶肥大和肿瘤学结局的证据。利用MEDLINE、EMBASE和Cochrane图书馆对2008年至2020年发表的研究进行了系统的文献检索。共纳入16项研究，包括602例患者。对侧肝叶每周的中位动力学生长率为0.7%，并随时间略有下降。局部肿瘤控制率为84%。362例患者中有109例（30%）在放射性栓塞后进行了手术切除。虽然现有数据表明，在主要肝切除术前进行放射性栓塞是安全的，肿瘤学结局良好，但放射性栓塞的确切作用需要在对照临床试验中进行评估。
