Department of Forensic Medicine, University of Pécs Medical School, Szigeti út 12, H-7624 Pécs, Hungary.
Department of Anatomy, MTA-PTE PACAP Research Team, University of Pécs Medical School, Szigeti út 12, H-7624 Pécs, Hungary.
Int J Mol Sci. 2020 Jan 28;21(3):827. doi: 10.3390/ijms21030827.
Traumatic brain injury remains a growing public health concern and represents the greatest contributor to death and disability globally among all trauma-related injuries. There are limited clinical data regarding biomarkers in the diagnosis and outcome prediction of TBI. The lack of real effective treatment for recovery calls for research of TBI to be shifted into the area of prevention, treatment of secondary brain injury and neurorehabilitation. The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been reported to act as a hormone, a neuromodulator, a neurotransmitter and a trophic factor, and has been implicated in a variety of developmental and regenerative processes. The importance of PACAP in neuronal regeneration lies in the upregulation of endogenous PACAP and its receptors and the protective effect of exogenous PACAP after different central nervous system injury. The aim of this minireview is to summarize both the therapeutic and biomarker potential of the neuropeptide PACAP, as a novel possible target molecule presently being investigated in several human conditions including TBI, and with encouraging results in animal models of TBI.
创伤性脑损伤仍然是一个日益严重的公共卫生问题，也是全球所有与创伤相关的损伤中导致死亡和残疾的最大原因。关于生物标志物在创伤性脑损伤的诊断和预后预测中的应用，目前临床数据有限。由于缺乏真正有效的治疗方法来促进恢复，因此需要将创伤性脑损伤的研究转向预防、治疗继发性脑损伤和神经康复领域。神经肽垂体腺苷酸环化酶激活肽（PACAP）已被报道具有激素、神经调质、神经递质和营养因子的作用，并与多种发育和再生过程有关。PACAP 在神经元再生中的重要性在于内源性 PACAP 及其受体的上调，以及不同中枢神经系统损伤后外源性 PACAP 的保护作用。本篇综述的目的是总结神经肽 PACAP 的治疗和生物标志物潜力，因为它是目前正在研究的几种人类疾病（包括创伤性脑损伤）的新型潜在靶分子，并且在创伤性脑损伤动物模型中取得了令人鼓舞的结果。
