Faculty of Medicine, Bahri University, Khartoum, Sudan.
Department of Epidemiology, Tropical Medicine Research Institute, Khartoum, Sudan.
Hypertens Pregnancy. 2020 May;39(2):77-81. doi: 10.1080/10641955.2020.1725037. Epub 2020 Feb 3.
: To assess the associations between preeclampsia, methylenetetrahydrofolate reductase () , and reduced folate carrier-1 () gene polymorphism in Sudanese women.: A matched (for age and parity) case-control study was conducted in a tertiary hospital (Saad Abualila) in Khartoum, Sudan during February to September 2018. The cases were women with preeclampsia and healthy pregnant women were the controls (160 women in each arm of the study). Genotyping for and was performed by polymerase chain reaction-restriction fragment length polymorphism.: . . The variation was significantly more frequent in women with preeclampsia (16.2%) than in healthy pregnant women (1.8%) (OR = 10.1, 95% CI = 3.0-34.2, < 0.001). There was borderline significance in the variation, which was present in 2.50% of women with preeclampsia, but was not found in healthy pregnant women ( = 0.052).s: A higher prevalence of polymorphism in women with preeclampsia compared with healthy pregnant women suggests involvement of this variation in preeclampsia in Sudan.
评估苏丹妇女先兆子痫、亚甲基四氢叶酸还原酶 () 和叶酸载体蛋白-1 () 基因多态性之间的关联。
本研究是在 2018 年 2 月至 9 月于苏丹喀土穆的 Saad Abualila 三级医院进行的一项匹配（年龄和产次）病例对照研究。病例为患有先兆子痫的女性，健康孕妇为对照组（每组 160 名女性）。聚合酶链反应-限制性片段长度多态性用于检测 和 基因型。
共纳入 320 名妇女，其中 120 例患有先兆子痫，200 例为健康孕妇。 携带 CT 基因型的妇女发生先兆子痫的风险是携带 TT 基因型的妇女的 10.1 倍（95%CI：3.0-34.2，<0.001）。 携带 677 位 C 等位基因的妇女发生先兆子痫的风险是携带 677 位 T 等位基因的妇女的 1.6 倍（95%CI：1.1-2.3，<0.001）。 在携带 677 位 T 等位基因的妇女中， 变体的频率在先兆子痫组（16.2%）中显著高于对照组（1.8%）（OR=10.1，95%CI=3.0-34.2，<0.001）。 变体的频率在先兆子痫组（2.50%）中存在，但在对照组中未发现（=0.052），具有边缘显著性。
与健康孕妇相比，先兆子痫妇女 变体的发生率较高，提示该变异与苏丹的先兆子痫有关。
