Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, PR China; Institute of Digestive Diseases, Xuzhou Medical University Xuzhou Jiangsu, 221006, PR China.
Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, PR China; Institute of Digestive Diseases, Xuzhou Medical University Xuzhou Jiangsu, 221006, PR China.
Am J Surg. 2020 Sep;220(3):725-730. doi: 10.1016/j.amjsurg.2020.01.041. Epub 2020 Jan 28.
Sleeve gastrostomy (SG) induces significant weight loss primarily as a result of increased satiety and reduced food intake. Growth differentiation factor-15 (GDF15) is a satiety hormone which induces a dramatic reduction of food intake and body weight.
To assess the effect of sleeve gastrectomy on plasma GDF 15 level and the association with the weight loss and diabetes control after SG.
We assessed plasma GDF15 level in 21 patients (15 with obesity and 6 with obesity and diabetes) before and then at 1, 3 and 12 months after SG.
GDF15 was significantly increased at 1 month after SG compared to before surgery level (301.9 ± 135.2 pg/ml vs 215.1 ± 119.9 pg/ml, respectively p<0.05) and increased even further at 3 months (338.86 ± 131.14 pg/ml, p<0.01) and remain elevated at 12 months (329.39 ± 152.1 pg/ml p<0.05) after SG. At 3 months after surgery, the increased GDF15 level was correlated with the magnitude of BMI loss (r = 0.204, p<0.05).
SG induces a significant increase in GDF15 level which is correlated with the magnitude of BMI loss.
袖状胃切除术（SG）主要通过增加饱腹感和减少食物摄入量来引起显著的体重减轻。生长分化因子 15（GDF15）是一种饱腹感激素，可显著减少食物摄入和体重。
评估袖状胃切除术对血浆 GDF15 水平的影响，以及与 SG 后体重减轻和糖尿病控制的关系。
我们评估了 21 例患者（15 例肥胖和 6 例肥胖合并糖尿病）在 SG 前后 1、3 和 12 个月的血浆 GDF15 水平。
与术前水平相比，SG 后 1 个月 GDF15 显著升高（301.9±135.2 pg/ml 比 215.1±119.9 pg/ml，p<0.05），3 个月时进一步升高（338.86±131.14 pg/ml，p<0.01），SG 后 12 个月仍升高（329.39±152.1 pg/ml，p<0.05）。术后 3 个月，GDF15 水平升高与 BMI 减轻幅度相关（r=0.204，p<0.05）。
SG 诱导 GDF15 水平显著升高，与 BMI 减轻幅度相关。
