Herbert Matthew S, Malaktaris Anne L, Lyons Robert, Norman Sonya B
Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA; Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA; Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Psychiatry Res. 2020 Jan 27;285:112820. doi: 10.1016/j.psychres.2020.112820.
Despite the well-known co-occurrence of posttraumatic stress disorder (PTSD) and chronic pain, large gaps remain in understanding how these two conditions influence each other. The aim of the present study was to examine the association between trauma-related guilt and pain among veterans with PTSD. Participants were 140 veterans enrolling in treatment for PTSD and alcohol use disorder. Trauma-related guilt was assessed by the trauma-related guilt inventory, including the global guilt, distress, and guilt cognitions scales. Measures of pain included pain severity, pain disability, and fear of pain. Several significant bivariate associations were observed between trauma-related guilt scales and pain outcomes; however, in linear regression models, only the association between thoughts of trauma-related guilt and fear of pain remained statistically significant after controlling for confounding factors. Further, thoughts of trauma-related guilt, specifically thoughts of wrongdoing, partially mediated the association between PTSD severity and fear of pain. Our findings suggest that trauma-related guilt may play a role in the relationship between PTSD and chronic pain. Future research is encouraged to examine thoughts of trauma-related guilt as a potential therapeutic target in the treatment of persons with comorbid PTSD and chronic pain.
尽管创伤后应激障碍(PTSD)和慢性疼痛经常同时出现,但在理解这两种状况如何相互影响方面仍存在很大差距。本研究的目的是检验患有创伤后应激障碍的退伍军人中与创伤相关的内疚感和疼痛之间的关联。参与者为140名参加创伤后应激障碍和酒精使用障碍治疗的退伍军人。通过创伤相关内疚感量表评估与创伤相关的内疚感,该量表包括总体内疚感、痛苦和内疚认知量表。疼痛的测量指标包括疼痛严重程度、疼痛残疾程度和对疼痛的恐惧。在与创伤相关的内疚感量表和疼痛结果之间观察到了几个显著的双变量关联;然而,在多元线性回归模型中,在控制混杂因素后,只有与创伤相关的内疚感想法和对疼痛的恐惧之间的关联在统计上仍然显著。此外,与创伤相关的内疚感想法,特别是关于做错事的想法,部分介导了创伤后应激障碍严重程度与对疼痛的恐惧之间的关联。我们的研究结果表明,与创伤相关的内疚感可能在创伤后应激障碍和慢性疼痛之间的关系中起作用。鼓励未来的研究将与创伤相关的内疚感想法作为治疗创伤后应激障碍和慢性疼痛共病患者的潜在治疗靶点进行研究。