Aoyama H, Yoshida M, Yamamura Y
Department of Public Health, St. Marianna University School of Medicine, Kawasaki, Japan.
Toxicology. 1988 Dec 16;53(1):11-8. doi: 10.1016/0300-483x(88)90232-6.
Thallous malonate was administered orally to hamsters in a single dose of 10 mg Tl/kg or 50 mg Tl/kg body weight. After 1 day and 3 days the levels of lipid peroxidation and non-protein sulfhydryls (NPSH) and glutathione peroxidase (GSH-Px) activity in tissues were measured. At a thallium dose of 10 mg/kg, increases in lipid peroxidation were already apparent in the kidney after 1 day. On the other hand, a marked increase in lipid peroxidation with decrease in NPSH content and GSH-Px activity in the kidney and liver were found 3 days after administration of the 50 mg Tl/kg dose, and renal and liver damage also developed. These results suggested that thallous malonate-induced tissue damage may be associated with the development of peroxidative processes caused by depression of GSH and inhibition of the GSH-Px activity-linked defensive system.
将丙二酸亚铊以10毫克铊/千克或50毫克铊/千克体重的单剂量口服给予仓鼠。在1天和3天后，测量组织中脂质过氧化、非蛋白巯基（NPSH）和谷胱甘肽过氧化物酶（GSH-Px）活性水平。在铊剂量为10毫克/千克时，1天后肾脏中脂质过氧化增加已很明显。另一方面，在给予50毫克铊/千克剂量3天后，发现肾脏和肝脏中脂质过氧化显著增加，同时NPSH含量和GSH-Px活性降低，并且肾脏和肝脏也出现了损伤。这些结果表明，丙二酸亚铊诱导的组织损伤可能与由于谷胱甘肽（GSH）减少和GSH-Px活性相关防御系统受抑制而导致的过氧化过程发展有关。
