不同高剂量率近距离放疗技术治疗宫颈癌患者的选择标准和临床结局。
Selection Criteria and Clinical Outcomes of Patients With Asymmetrical Cervical Cancer Treated With Various High-dose-rate Brachytherapy Techniques.
机构信息
Radiation Oncology Department, Cancer Institute Hospital, the Japanese Foundation for Cancer Research, Tokyo, Japan
Department of Radiation Oncology & Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan.
出版信息
Anticancer Res. 2020 Feb;40(2):999-1006. doi: 10.21873/anticanres.14034.
BACKGROUND/AIM: We aimed to evaluate the efficacy of high-dose-rate brachytherapy techniques selected according to pre-brachytherapy magnetic resonance imaging (MRI) findings in asymmetrical cervical cancer (ACC).
PATIENTS AND METHODS
We analyzed 33 ACC patients. Asymmetric tumors were defined as those in which the difference between the distance from the cervical canal to the farthest end of the tumor [long distance (LD)] and the distance from the cervical canal to the contralateral tumor edge [short distance (SD)] is equal to or greater than 2 cm on the basis of MRI prior to treatment. On pre-treatment and pre-brachytherapy MRI, the median LDs were 40 mm and 21 mm, respectively. Patients with LD≥2 cm and LD - SD≥1 cm on pre-brachytherapy MRI received non-conventional intracavitary brachytherapy (ICBT).
RESULTS
Sixteen patients (48%) received non-conventional ICBT. There was no significant difference in 3-year local control between the two treatment groups (100% vs. 81.2%, p=0.07); two patients had grade 2 radiation proctitis.
CONCLUSION
Brachytherapy techniques selected according to pre-brachytherapy MRI findings were effective for ACC treatment.
背景/目的：我们旨在评估根据治疗前磁共振成像（MRI）发现选择的高剂量率近距离放疗技术在非对称宫颈癌（ACC）中的疗效。
患者和方法
我们分析了 33 例 ACC 患者。不对称肿瘤是指基于治疗前 MRI，肿瘤最远端到宫颈管的距离[长距离（LD）]与肿瘤对侧边缘到宫颈管的距离[短距离（SD）]之间的差值等于或大于 2cm。在治疗前和治疗前的 MRI 上，LD 的中位数分别为 40mm 和 21mm。LD≥2cm 和 LD-SD≥1cm 的患者接受非传统腔内近距离放疗（ICBT）。
结果
16 例（48%）患者接受了非传统 ICBT。两组 3 年局部控制率无显著差异（100%与 81.2%，p=0.07）；两名患者出现 2 级放射性直肠炎。
结论
根据治疗前 MRI 发现选择的近距离放疗技术对 ACC 的治疗有效。
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