Division of Plastic Surgery and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL, U.S.A.
Department of Surgery, Mayo Clinic, Jacksonville, FL, U.S.A.
Anticancer Res. 2020 Feb;40(2):1059-1063. doi: 10.21873/anticanres.14043.
BACKGROUND/AIM: The surgical management of invasive melanoma has been debated for many years and recommended excisional margins have been established. We aimed to describe the factors and survival related to the presence of residual tumor in patients with invasive melanoma lymph nodes negative.
We performed a retrospective study by querying the National Cancer Database from 2004 to 2015. Associations were tested using a multivariate analysis. Overall survival was compared using the Kaplan-Meier method.
A total of 26,440 patients met the inclusion criteria. For Breslow depth groups ≤1 mm and >2 mm, older age and location in the head and neck were factors associated to residual tumor in margins (p<0.05), whereas only location in the head and neck was associated to residual tumor for patients with Breslow depth between 1.01-2.00 mm (p<0.05).
Knowledge of the factors associated with the residual tumor will help establish a patient-centered management and decrease the recurrence of disease.
背景/目的：侵袭性黑色素瘤的手术治疗多年来一直存在争议，已确立了推荐的切除边缘。我们旨在描述无侵袭性黑色素瘤淋巴结转移的患者中存在肿瘤残留的相关因素和生存情况。
我们通过查询 2004 年至 2015 年的国家癌症数据库进行了回顾性研究。使用多变量分析检验相关性。使用 Kaplan-Meier 方法比较总生存率。
共有 26440 名患者符合纳入标准。对于 Breslow 深度≤1mm 和>2mm 的患者，年龄较大和头颈部位置是边缘存在肿瘤残留的相关因素（p<0.05），而仅头颈部位置与 Breslow 深度在 1.01-2.00mm 之间的患者存在肿瘤残留相关（p<0.05）。
了解与肿瘤残留相关的因素将有助于制定以患者为中心的管理方案，并降低疾病复发的风险。
