Kudo M, Nagayama T
Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
Stroke. 1988 Dec;19(12):1544-9. doi: 10.1161/01.str.19.12.1544.
Using light and electron microscopy, we studied the interaction between lipids and host tissue for up to 15 days after experimentally produced cerebral infarcts in 16 rats. A lipid-dense zone was formed along the periphery of the infarcts before a glial response started; a glycogen-rich zone appeared peripheral to the lipid zone. Macrophages and astrocytes then started to proliferate in the lipid and glycogen-rich zones. The cerebral tissue within the lipid zone underwent complete necrosis. Ultrastructurally, lipids were observed in the edematous areas as well as in various types of hematogenous and resident cells. Glycogen granules were present mainly in the astrocytic processes. Macrophages rapidly evolved into foamy macrophages in the central necrotic areas, whereas foamy transformation was not striking in the peripheral, less injured areas. Reactive fibrous astrocytes also contained varying amounts of lipids. The exact biologic significance of the lipid zone in the premacrophagic stage remains unclear; however, since lipids are hydrophobic, they may function as a barrier against edema fluid extension into the adjacent tissue.
利用光学显微镜和电子显微镜，我们在16只大鼠实验性制造脑梗死之后，研究了长达15天的脂质与宿主组织之间的相互作用。在胶质反应开始之前，沿着梗死灶周边形成了一个脂质密集区；在脂质区外周出现了一个富含糖原的区域。然后巨噬细胞和星形胶质细胞开始在富含脂质和糖原的区域增殖。脂质区内的脑组织发生了完全坏死。在超微结构上，在水肿区域以及各种类型的血源性细胞和驻留细胞中都观察到了脂质。糖原颗粒主要存在于星形胶质细胞的突起中。巨噬细胞在中央坏死区域迅速演变成泡沫状巨噬细胞，而在周边损伤较轻的区域，泡沫样转变并不明显。反应性纤维性星形胶质细胞也含有不同数量的脂质。巨噬细胞前阶段脂质区的确切生物学意义仍不清楚；然而，由于脂质是疏水性的，它们可能起到防止水肿液扩展到相邻组织的屏障作用。
