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新型的依赖反式激活转录蛋白的蛋白质分泌

Novel Tat-Dependent Protein Secretion.

作者信息

Braun Volkmar, Hantke Klaus

机构信息

Max Planck Institute for Developmental Biology, Department of Protein Evolution, Tübingen, Germany

IMID Institute, University of Tübingen, Tübingen, Germany.

出版信息

J Bacteriol. 2020 Apr 9;202(9). doi: 10.1128/JB.00058-20.

DOI:10.1128/JB.00058-20
PMID:32015148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7148135/
Abstract

The transcription initiation signal elicited by the binding of ferric citrate to the outer membrane FecA protein is transmitted by the FecR protein across the cytoplasmic membrane to the FecI extracytoplasmic function (ECF) sigma factor. In this issue of , I. J. Passmore, J. M. Dow, F. Coll, J. Cuccui, et al. (J Bacteriol 202:e00541-19, 2020, https://doi.org/10.1128/JB.00541-19) report that the FecR sequence contains both the twin-arginine signal motif and the secretory (Sec) avoidance motif typical of proteins secreted by the twin-arginine translocation (TAT) system. The same study shows that FecR is indeed secreted by Tat and represents a new class of bitopic Tat-dependent membrane proteins.

摘要

柠檬酸铁与外膜FecA蛋白结合所引发的转录起始信号，由FecR蛋白穿过细胞质膜传递给FecI胞外功能（ECF）σ因子。在本期杂志中，I. J. 帕斯莫尔、J. M. 道、F. 科尔、J. 库库伊等人（《细菌学杂志》202:e00541 - 19, 2020, https://doi.org/10.1128/JB.00541 - 19）报告称，FecR序列同时包含双精氨酸信号基序和双精氨酸转运（TAT）系统分泌蛋白所特有的分泌（Sec）回避基序。同一研究表明，FecR确实是由Tat分泌的，并且代表了一类新的双位Tat依赖性膜蛋白。

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本文引用的文献

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Ferric Citrate Regulator FecR Is Translocated across the Bacterial Inner Membrane via a Unique Twin-Arginine Transport-Dependent Mechanism.柠檬酸铁调控因子 FecR 通过独特的双精氨酸转运依赖机制穿过细菌内膜转运。
J Bacteriol. 2020 Apr 9;202(9). doi: 10.1128/JB.00541-19.
2
Cryo-EM structure of the bacterial Ton motor subcomplex ExbB-ExbD provides information on structure and stoichiometry.细菌 Ton 动力亚基复合物 ExbB-ExbD 的冷冻电镜结构提供了结构和组成信息。
Commun Biol. 2019 Oct 4;2:358. doi: 10.1038/s42003-019-0604-2. eCollection 2019.
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Structural insight into the role of the Ton complex in energy transduction.对转运体复合物在能量转导中作用的结构洞察。
Nature. 2016 Oct 6;538(7623):60-65. doi: 10.1038/nature19757. Epub 2016 Sep 21.
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Biochemistry. 2011 Oct 18;50(41):8950-6. doi: 10.1021/bi2008195. Epub 2011 Sep 21.
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Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane--distinct translocases and mechanisms.Sec和Tat介导的蛋白质跨细菌细胞质膜分泌——不同的转运体和机制。
Biochim Biophys Acta. 2008 Sep;1778(9):1735-56. doi: 10.1016/j.bbamem.2007.07.015. Epub 2007 Aug 9.
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