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人头皮组织中 telocytes 的超微结构和免疫组织化学特征。

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue.

机构信息

Department of Dermatology, the Third Affiliated Hospital of Soochow University, 185 Juqian Road, Changzhou, 213003, Jiangsu Province, People's Republic of China.

Department of Dermatology, the First Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu, 233030, Anhui Province, People's Republic of China.

出版信息

Sci Rep. 2020 Feb 3;10(1):1693. doi: 10.1038/s41598-020-58628-w.

DOI:10.1038/s41598-020-58628-w
PMID:32015359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6997163/
Abstract

This study was designed to characterize the location, morphology and ultrastructure of telocytes (TCs) in human scalp tissue. After obtaining approval for this study and informed consent from the patient, a scalp specimen was obtained. The distribution and morphology of TCs in human scalp tissue was assessed by immunohistochemical staining of CD34 and CD117/c-KIT, and the ultrastructure of TCs was investigated using transmission electron microscopy (TEM). Immunohistochemical staining of CD34 revealed that TCs were located in the connective tissue of human scalp, and were concentrated around hair follicles (HFs), blood vessels, sweat glands, sebaceous glands and adipose lobules. Immunohistochemical staining of CD117 revealed that TCs were mainly located in the dermis of human scalp, surrounding the HFs and sweat glands. Under TEM, TCs were seen and confirmed by their special morphological features. These cells were spindle-shaped, had small cell bodies and long thin processes, and surrounded stem cell clusters in the bulge region of HFs. These results demonstrate that TCs in human scalp were positive for CD34 and CD117, and their strategic positioning surrounding stem cells suggests their possible involvement in local regeneration, remodeling and homeostasis of the skin.

摘要

本研究旨在描述人头皮组织中 telocytes（TCs）的位置、形态和超微结构。在获得该研究的批准和患者的知情同意后，获得头皮标本。通过对 CD34 和 CD117/c-KIT 的免疫组织化学染色评估人头皮组织中 TCs 的分布和形态，并用透射电子显微镜（TEM）研究 TCs 的超微结构。CD34 的免疫组织化学染色显示 TCs 位于人头皮的结缔组织中，集中在毛囊（HFs）、血管、汗腺、皮脂腺和脂肪小叶周围。CD117 的免疫组织化学染色显示 TCs 主要位于人头皮的真皮中，围绕 HFs 和汗腺。在 TEM 下，通过其特殊的形态特征观察并确认 TCs。这些细胞呈梭形，细胞体小而细长的突起，围绕 HFs 的隆起区域中的干细胞簇。这些结果表明人头皮中的 TCs 对 CD34 和 CD117 呈阳性，它们围绕干细胞的战略定位表明它们可能参与皮肤的局部再生、重塑和内稳态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4d8ae2bb80c4/41598_2020_58628_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/e080d5d6132b/41598_2020_58628_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4d1bb9f9105a/41598_2020_58628_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4181f2d5e9b7/41598_2020_58628_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/74ee5537eed5/41598_2020_58628_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4d8ae2bb80c4/41598_2020_58628_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/e080d5d6132b/41598_2020_58628_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4d1bb9f9105a/41598_2020_58628_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4181f2d5e9b7/41598_2020_58628_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/74ee5537eed5/41598_2020_58628_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d56/6997163/4d8ae2bb80c4/41598_2020_58628_Fig5_HTML.jpg

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