Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, Poland.
Department of Trauma and Orthopaedics, District Trauma and Orthopaedic Hospital, Piekary Sląskie, Poland.
PLoS One. 2020 Feb 3;15(2):e0226950. doi: 10.1371/journal.pone.0226950. eCollection 2020.
An increased prevalence of allergies and an increased incidence of breast cancer have been observed. The hypothesis that atopy may have a protective effect against the risk of different types of breast cancer was evaluated.
In this study, 11,101 patients (11,101 women with a mean age of 55.2±14.7 years) with different types of breast cancer were tested for allergies. Allergies were confirmed based on the retrospective analysis of allergy diagnostic procedures in patients who had been previously diagnosed with breast cancer. The retrospective prevalence rates of active allergic diseases, including allergic rhinitis, bronchial asthma and atopic dermatitis, were assessed. All patients were also analyzed for bronchial asthma and allergic rhinitis according to the relevant guidelines. A group of healthy control patients was used for the comparisons.
The women with breast cancer had a significantly lower incidence of IgE-mediated allergic diseases than the controls. The odds ratios (ORs) for allergic rhinitis, atopic dermatitis, and bronchial asthma were 0.61 (95% CI: 0.57-0.73), 0.17 (95% CI: 0.11-0.44), and 0.73 (95% CI: 0.65-0.83), respectively. The mean serum concentrations of total IgE were significantly lower in the study population of women with breast cancer than in the patients of the control group (39.2 ± 26.2 kU/L vs. 108.5 ± 38.5 kU/L; p = 0.002).
Our results suggest that the overall incidence of allergies, especially allergic rhinitis, is lower in patients with certain types of cancer than in individuals who did not have cancer. Further studies are needed to confirm our findings.
过敏和乳腺癌的发病率都有所增加。有人假设特应性可能对不同类型乳腺癌的风险有保护作用，为此评估了这一假说。
本研究共纳入 11101 例（11101 例女性，平均年龄 55.2±14.7 岁）患有不同类型乳腺癌的患者，对其进行过敏检测。根据先前确诊为乳腺癌患者的过敏诊断程序的回顾性分析来确认过敏。评估了包括过敏性鼻炎、支气管哮喘和特应性皮炎在内的活动性过敏性疾病的回顾性患病率。根据相关指南，所有患者均进行支气管哮喘和过敏性鼻炎分析。并使用一组健康对照组进行比较。
患有乳腺癌的女性发生 IgE 介导的过敏性疾病的比例明显低于对照组。过敏性鼻炎、特应性皮炎和支气管哮喘的比值比（OR）分别为 0.61（95%CI：0.57-0.73）、0.17（95%CI：0.11-0.44）和 0.73（95%CI：0.65-0.83）。患有乳腺癌的女性研究人群的血清总 IgE 平均浓度明显低于对照组（39.2±26.2 kU/L 比 108.5±38.5 kU/L；p=0.002）。
我们的结果表明，某些类型癌症患者的过敏总体发生率，特别是过敏性鼻炎的发生率低于未患癌症的个体。需要进一步的研究来证实我们的发现。
