Rolevich Alexander, Yaumenenka Alesia, Borodin Denis, Semenov Sviataslau, Artsiushkevich Liudmila, Polyakov Sergey, Konoplia Natalia, Krasny Sergei
Department of Urology, N.N. Alexandrov National Research Cancer Center, Minsk, Belarus.
Department of Cancer Control, N.N. Alexandrov National Research Cancer Center, Minsk, Belarus.
Cent European J Urol. 2019;72(4):357-368. doi: 10.5173/ceju.2019.0073. Epub 2019 Dec 30.
The objective of this study was to assess recent trends in incidence, mortality and relative survival (RS) in testicular cancer (TC) patients in Belarus and to provide international comparisons of our figures.
We surveyed the Belarusian Cancer Registry for all male cases diagnosed with International Classification of Diseases for Oncology, third edition (ICD-O-3) topography code C62 between 1990 and 2015. Trends for incidence and mortality rates per 100,000 of the world standard population and annual percentage changes (APCs) were calculated. We also estimated the 1- and 5-year RS rates for the 1990-1998, 1999-2007 and 2008-2015 periods according to the Ederer II method. The RS estimates for the 2008-2015 period were age-standardized and compared with the published EUROCARE-5 data and SEER-18 database analysis.
A total of 2,500 and 2,439 cases were included into incidence and survival analyses, respectively. We found a significant increase in the TC age-standardized incidence rate (APC 2.6%) and a decline in the age-standardized mortality (APC -3.0%) over the study period. RS significantly increased in all patients` strata; a relative increase was more pronounced in advanced stages of seminoma and younger age groups. Nevertheless, the most recent figures of age-standardized RS including stage-specific estimates were generally worse than the European and SEER data.
We have found a significant increase in TC incidence in Belarus in recent years. Mortality has significantly declined with a corresponding increase in RS which, however, did not reach European or North American figures. Continued effort is required to improve the quality of management of TC patients in our country.
本研究的目的是评估白俄罗斯睾丸癌（TC）患者的发病率、死亡率和相对生存率（RS）的近期趋势，并对我们的数据进行国际比较。
我们对白俄罗斯癌症登记处进行了调查，纳入了1990年至2015年间按照国际肿瘤疾病分类第三版（ICD-O-3）地形编码C62诊断的所有男性病例。计算了每10万世界标准人口的发病率和死亡率趋势以及年度百分比变化（APC）。我们还根据埃德勒二世方法估计了1990 - 1998年、1999 - 2007年和2008 - 2015年期间的1年和5年RS率。对2008 - 2015年期间的RS估计值进行了年龄标准化，并与已发表的EUROCARE - 5数据和SEER - 18数据库分析结果进行了比较。
分别有2500例和2439例病例纳入发病率和生存分析。我们发现，在研究期间，TC年龄标准化发病率显著上升（APC为2.6%），年龄标准化死亡率下降（APC为 - 3.0%）。所有患者分层中的RS均显著增加；在精原细胞瘤晚期和较年轻年龄组中相对增加更为明显。然而，包括特定阶段估计值在内的最新年龄标准化RS数据总体上比欧洲和SEER数据要差。
我们发现近年来白俄罗斯的TC发病率显著上升。死亡率显著下降，RS相应增加，但未达到欧洲或北美的水平。我国需要持续努力提高TC患者的管理质量。
