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Can immune biomarkers predict benefit from targeted agents in metastatic renal cell carcinoma?

作者信息

Pichler Renate, Schmidinger Manuela

机构信息

Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.

Department of Medicine I, Clinical Division of Oncology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

出版信息

Ann Transl Med. 2019 Dec;7(Suppl 8):S275. doi: 10.21037/atm.2019.11.138.

DOI:10.21037/atm.2019.11.138
PMID:32015994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6976423/
Abstract
摘要

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Expert Opin Investig Drugs. 2019 Oct;28(10):851-860. doi: 10.1080/13543784.2019.1673366. Epub 2019 Oct 3.
2
PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN.帕博利珠单抗、依维莫司和舒尼替尼治疗转移性肾细胞癌患者的 PD-L1 表达与临床结局：METEOR 和 CABOSUN 随机临床试验分析。
Clin Cancer Res. 2019 Oct 15;25(20):6080-6088. doi: 10.1158/1078-0432.CCR-19-1135. Epub 2019 Aug 1.
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Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.阿维鲁单抗联合阿昔替尼与舒尼替尼治疗晚期肾细胞癌。
N Engl J Med. 2019 Mar 21;380(12):1103-1115. doi: 10.1056/NEJMoa1816047. Epub 2019 Feb 16.
4
Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma.派姆单抗联合阿昔替尼对比舒尼替尼用于晚期肾细胞癌。
N Engl J Med. 2019 Mar 21;380(12):1116-1127. doi: 10.1056/NEJMoa1816714. Epub 2019 Feb 16.
5
Immune context characterization and heterogeneity in primary tumors and pulmonary metastases from renal cell carcinoma.肾细胞癌原发肿瘤和肺转移灶的免疫背景特征及异质性。
Immunotherapy. 2019 Jan;11(1):21-35. doi: 10.2217/imt-2018-0097.
6
Systemic Treatment of Metastatic Clear Cell Renal Cell Carcinoma in 2018: Current Paradigms, Use of Immunotherapy, and Future Directions.2018 年转移性透明细胞肾细胞癌的系统治疗：当前范例、免疫治疗的应用及未来方向。
Eur Urol. 2019 Jan;75(1):100-110. doi: 10.1016/j.eururo.2018.10.010. Epub 2018 Oct 13.
7
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.纳武利尤单抗联合伊匹木单抗与舒尼替尼治疗晚期肾细胞癌的比较
N Engl J Med. 2018 Apr 5;378(14):1277-1290. doi: 10.1056/NEJMoa1712126. Epub 2018 Mar 21.
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Immunomodulatory Effects of Tyrosine Kinase Inhibitor In Vitro and In Vivo Study.酪氨酸激酶抑制剂的体外和体内免疫调节作用研究。
Biol Blood Marrow Transplant. 2018 Feb;24(2):267-275. doi: 10.1016/j.bbmt.2017.10.039. Epub 2017 Nov 8.
9
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.依赖受体酪氨酸激酶 c-MET 的反应性中性粒细胞反应限制了癌症免疫治疗。
Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.
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Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial.卡博替尼对比舒尼替尼作为低危或中危转移性肾细胞癌患者的初始靶向治疗：联盟A031203 CABOSUN试验
J Clin Oncol. 2017 Feb 20;35(6):591-597. doi: 10.1200/JCO.2016.70.7398. Epub 2016 Nov 14.