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Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy.错配修复缺陷/微卫星不稳定高作为抗 PD-1/PD-L1 免疫治疗疗效的预测指标。
J Hematol Oncol. 2019 May 31;12(1):54. doi: 10.1186/s13045-019-0738-1.
3
The new era of precision medicine in hepatocellular carcinoma: the urgent need for promising biomarkers.肝细胞癌精准医学的新时代：对有前景生物标志物的迫切需求。
Hepatobiliary Surg Nutr. 2018 Dec;7(6):490-491. doi: 10.21037/hbsn.2018.08.06.
4
Study progression of anti-angiogenetic therapy and its combination with other agents for the treatment of advanced hepatocellular carcinoma.抗血管生成疗法及其与其他药物联合治疗晚期肝细胞癌的研究进展。
Hepatobiliary Surg Nutr. 2018 Dec;7(6):466-474. doi: 10.21037/hbsn.2018.11.04.
5
Modelling cancer in microfluidic human organs-on-chips.在微流控人体器官芯片中模拟癌症。
Nat Rev Cancer. 2019 Feb;19(2):65-81. doi: 10.1038/s41568-018-0104-6.
6
Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade.分析前列腺癌中微卫星不稳定性的流行情况及对免疫检查点阻断的反应。
JAMA Oncol. 2019 Apr 1;5(4):471-478. doi: 10.1001/jamaoncol.2018.5801.
7
Organoid Modeling of the Tumor Immune Microenvironment.类器官肿瘤免疫微环境模型构建
Cell. 2018 Dec 13;175(7):1972-1988.e16. doi: 10.1016/j.cell.2018.11.021.
8
Patient-derived organoids: a promising model for personalized cancer treatment.患者来源的类器官：个性化癌症治疗的一个有前景的模型。
Gastroenterol Rep (Oxf). 2018 Nov;6(4):243-245. doi: 10.1093/gastro/goy040. Epub 2018 Oct 9.
9
Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade.组氨酸靶向髓系来源的抑制细胞，提高 PD-1/PD-L1 检查点阻断的抗肿瘤疗效。
Cancer Immunol Immunother. 2019 Feb;68(2):163-174. doi: 10.1007/s00262-018-2253-6. Epub 2018 Oct 12.
10
Organoids in cancer research.类器官在癌症研究中的应用。
Nat Rev Cancer. 2018 Jul;18(7):407-418. doi: 10.1038/s41568-018-0007-6.

Programmed cell death protein 1/programmed death ligand-1 checkpoint blockade meets patient-derived organoids.

作者信息

Sun Lejia, Yang Huayu, Mao Yilei

机构信息

Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing 100730, China.

出版信息

Ann Transl Med. 2019 Dec;7(Suppl 8):S287. doi: 10.21037/atm.2019.11.76.

DOI:10.21037/atm.2019.11.76
PMID:32016006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6976394/
Abstract
摘要